The rise of T-type channels in melanoma progression and chemotherapeutic resistance

被引：8

作者：

Alza, Lia ^{[1
]}

Visa, Anna ^{[1
]}

Herreros, Judit ^{[1
]}

Canti, Carles ^{[1
]}

机构：

[1] Univ Lleida IRBlLeida, Cell Calcium Signaling Lab, Rovira Roure 80, Lleida 25198, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2020年 / 1873卷 / 02期

关键词：

Melanoma; T-type channels; MAPK; RAF/RAS mutants; PTEN mutants; Macroautophagy; Chemotherapeutic resistance; CALCIUM-CHANNELS; CA2+ CHANNELS; CELL-CYCLE; INHIBITION; AUTOPHAGY; CANCER; INDUCTION; INACTIVATION; METHYLATION; EXPRESSION;

D O I：

10.1016/j.bbcan.2020.188364

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hyperactivation of the Mitogen Activated Protein Kinase (MAPK) pathway is prevalent in melanoma, principally due to mutations in the BRAF and NRAS genes. MAPK inhibitors are effective only short-term, and recurrence occurs due to functional redundancies or intertwined pathways. The remodeling of Ca2+ signaling is also common in melanoma cells, partly through the increased expression of T-type channels (TTCCs). Here we summarize current knowledge about the prognostic value and molecular targeting of TTCCs. Furthermore, we discuss recent evidence pointing to TTCCs as molecular switches for melanoma chemoresistance, which set the grounds for novel combined therapies against the advanced disease.

引用

页数：6

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