N-Phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones:: in vivo active AMPA and NMDA(glycine) antagonists.

被引：31

作者：

Auberson, YP ^{[1
]}

Acklin, P ^{[1
]}

Bischoff, S ^{[1
]}

Moretti, R ^{[1
]}

Ofner, S ^{[1
]}

Schmutz, M ^{[1
]}

Veenstra, SJ ^{[1
]}

机构：

[1] Novartis Pharma AG, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(98)00720-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Substituted 5-aminomethylquinoxalinediones containing carboxy or phosphonic acids yield potent and selective AMPA and/or NMDA (glycine-binding site) antagonists. Phosphonic acid derivatives are particularly water-soluble and display potent anticonvulsant effects in the electroshock-induced convulsion assay in mice. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：249 / 254

页数：6

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