Development of Repeatable Microcatheter Access Port for Intra-arterial Therapy of Liver Cancer

被引：3

作者：

Fukuoka, Yasushi ^{[1
]}

Tanaka, Toshihiro ^{[1
]}

Nishiofuku, Hideyuki ^{[1
]}

Sato, Takeshi ^{[1
]}

Masada, Tetsuya ^{[1
]}

Tatsumoto, Shota ^{[1
]}

Marugami, Nagaaki ^{[1
]}

Sakaguchi, Hiroshi ^{[2
]}

Kichikawa, Kimihiko ^{[1
]}

机构：

[1] Nara Med Univ, Dept Radiol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan

[2] Minaminara Med Ctr, Dept Radiol, Oyodo, Japan

来源：

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY | 2019年 / 42卷 / 02期

关键词：

Transarterial chemoembolization; Hepatic arterial infusion chemotherapy; Implantable port; HEPATIC ARTERIAL INFUSION; DEGRADABLE STARCH MICROSPHERES; ELUTING BEADS DEBIRI; COLORECTAL METASTASES; CATHETER SYSTEM; CHEMOEMBOLIZATION; IRINOTECAN; PHARMACOKINETICS; 5-FLUOROURACIL; EFFICACY;

D O I：

10.1007/s00270-018-2111-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PurposeTo develop an implantable port in which a microcatheter can be inserted for a combination therapy of repeated transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for advanced liver cancer.Materials and MethodsThe design of a currently used implantable port was modified. A funnel part was constructed in the port. The septum was punctured by a 20-gauge indwelling needle, and 2.0-Fr non-tapered microcatheter was inserted into the port. In the in vitro studies, the advance of a microcatheter out of the funnel part was evaluated via seven different septum puncture sites. A 5-Fr indwelling catheter connected to the port was placed in a vascular model, and a microcatheter catheterization was evaluated. In an in vivo study, the port-catheter system was implanted in the hepatic artery in a pig. A microcatheter was percutaneously inserted through the port into the hepatic arterial branches, and embolization was performed.ResultsIn the in vitro studies, the microcatheter was smoothly advanced out of the port and catheterizations into the hepatic arteries were successful via all septum puncture sites. In the in vivo study, repeated selective embolization through the port was successfully conducted on 7, 14 and 21days after the implantation.ConclusionThe developed implantable port can be used for repeated catheter insertion into the hepatic artery. The combination of repeated TACE and HAIC could be possible using this device.

引用

页码：298 / 303

页数：6