Association between Levels of Urine Di-(2-ethylhexyl)phthalate Metabolites and Heart Rate Variability in Young Adults

被引：12

作者：

Chen, Ching-Way ^{[1
]}

Tang, Shu-Yu ^{[1
]}

Hwang, Jin-Shiang ^{[2
]}

Chan, Chang-Chuan ^{[3
]}

Hsu, Cheng-Chih ^{[4
]}

Lin, Chien-Yu ^{[5
]}

Su, Ta-Chen ^{[3
,6
,7
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Yunlin Branch, Yunlin 640203, Taiwan

[2] Acad Sinica, Inst Stat Sci, Taipei 11529, Taiwan

[3] Natl Taiwan Univ, Inst Environm & Occupat Hlth Sci, Coll Publ Hlth, Taipei 10017, Taiwan

[4] Natl Taiwan Univ, Dept Chem, Taipei 10017, Taiwan

[5] En Chu Kong Hosp, Dept Internal Med, New Taipei 237414, Taiwan

[6] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei 10002, Taiwan

[7] Natl Taiwan Univ Hosp, Div Cardiol, Dept Internal Med, Taipei 10002, Taiwan

来源：

TOXICS | 2021年 / 9卷 / 12期

关键词：

plasticizers; di-(2-ethylhexyl) phthalate; health assessment; heart rate variability; young adults; FREQUENCY-DOMAIN MEASURES; PHTHALATE METABOLITES; DI(2-ETHYLHEXYL)PHTHALATE DEHP; OXIDATIVE STRESS; NATIONAL-HEALTH; MORTALITY; RISK; ATHEROSCLEROSIS; DISEASE; NHANES;

D O I：

10.3390/toxics9120351

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Phthalate exposure is associated with cardiovascular risk. Among the various phthalates, di-(2-ethylhexyl) phthalate (DEHP) is a deleterious plasticizer in our daily lives. This study investigated the association between DEHP exposure and the alteration of heart rate variability (HRV). During 2017-2019, we recruited 974 young adults to investigate the effects of living environments and dietary habits on cardiometabolic disorders in Taiwan. We quantitatively analyzed urinary metabolites of DHEP. A continuous electrocardiogram was recorded to obtain a 5-min ECG. Time-domain and frequency-domain HRV analyses were performed. Multiple linear regression showed that urinary oxidized DEHP metabolites MEHHP and MEOHP were associated with decreased HRV after controlling for associated cardiovascular risk factors. A higher MEHHP level was associated with a lower triangular interpolation of NN interval histogram (TINN), very low frequency (VLF), and low frequency/high frequency (LF/HF) ratio. A higher MEOHP level was associated with a decreased LF/HF ratio. In addition, trend analysis showed that higher MEHHP and MEOHP quantiles were significantly associated with a decreased LF/HF ratio. DEHP is a potentially harmful and invisible chemical. The urinary DEHP metabolites MEHHP and MEOHP are associated with decreased HRV, indicating an adverse effect on autonomic balance in young adults in Taiwan.

引用

页数：12

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