Effect of Physical Activity, Smoking, and Sleep on Telomere Length: A Systematic Review of Observational and Intervention Studies

被引:40
作者
Barragan, Rocio [1 ,2 ,3 ,4 ]
Ortega-Azorin, Carolina [1 ,2 ]
Sorli, Jose V. [1 ,2 ]
Asensio, Eva M. [1 ,2 ]
Coltell, Oscar [2 ,5 ]
St-Onge, Marie-Pierre [3 ,4 ]
Portoles, Olga [1 ,2 ]
Corella, Dolores [1 ,2 ]
机构
[1] Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain
[2] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
[3] Columbia Univ, Dept Med, Sleep Ctr Excellence, Irving Med Ctr, New York, NY 10032 USA
[4] Columbia Univ, Dept Med, Div Gen Med, Irving Med Ctr, New York, NY 10032 USA
[5] Univ Jaume 1, Dept Comp Languages & Syst, Castellon de La Plana 12071, Spain
关键词
aging; telomere length; physical activity; exercise; tobacco; smoking; sleep; lifestyle; BLOOD-MONONUCLEAR-CELLS; CORONARY-HEART-DISEASE; CIGARETTE-SMOKING; SEDENTARY BEHAVIOR; DIETARY PATTERNS; NUTRITION EXAMINATION; DNA METHYLATION; NATIONAL-HEALTH; OLDER-ADULTS; ASSOCIATION;
D O I
10.3390/jcm11010076
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aging is a risk factor for several pathologies, restricting one's health span, and promoting chronic diseases (e.g., cardiovascular and neurodegenerative diseases), as well as cancer. Telomeres are regions of repetitive DNA located at chromosomal ends. Telomere length has been inversely associated with chronological age and has been considered, for a long time, a good biomarker of aging. Several lifestyle factors have been linked with telomere shortening or maintenance. However, the consistency of results is hampered by some methodological issues, including study design, sample size, measurement approaches, and population characteristics, among others. Therefore, we aimed to systematically review the current literature on the effects of three relevant lifestyle factors on telomere length in human adults: physical activity, smoking, and sleep. We conducted a qualitative systematic review of observational and intervention studies using the Preferred Reporting Item for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The systematic literature search covered articles published in MEDLINE and EMBASE databases (from 2010 to 2020). A total of 1400 studies were identified; 83 were included after quality control. Although fewer sedentary activities, optimal sleep habits, and non- or ex-smoker status have been associated with less telomere shortening, several methodological issues were detected, including the need for more targeted interventions and standardized protocols to better understand how physical activity and sleep can impact telomere length and aging. We discuss the main findings and current limitations to gain more insights into the influence of these lifestyle factors on the healthy aging process.
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页数:26
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