The role of regulatory T lymphocytes in asthma pathogenesis

被引：33
|
作者：
Robinson, DS [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Biomed Sci Div,Leukocyte Biol Sect, London SW7 2AZ, England
来源：
CURRENT ALLERGY AND ASTHMA REPORTS | 2005年 / 5卷 / 02期
基金：
英国惠康基金;
关键词：
D O I：
10.1007/s11882-005-0087-8
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Several subtypes of regulatory or suppressive T cells have been described that can prevent activation of effector T cells in vitro and in vivo in animal models. Recent evidence suggests a deficit in suppressive activity of both CD4(+)CD25(+) regulatory T cells, and interleukin (IL)-10 producing regulatory T cells may play a role in development of allergic sensitization. If therapies can be devised to redress the balance between regulatory and effector T cells, there may be hope for the control and prevention of asthma.
引用
收藏
页码：136 / 141
页数：6
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