Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialyl Lewis X tetrasaccharide

被引：11
作者：
Hiruma, K
Kanie, O
Wong, CH
机构：
[1] RIKEN, Inst Phys & Chem Res, Frontier Res Program, Wako, Saitama 35101, Japan
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
TETRAHEDRON | 1998年 / 54卷 / 52期
关键词：
D O I：
10.1016/S0040-4020(98)00990-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methods have been developed for the incorporation of hydrophobic groups with and without positive or negative charge to position-6 of the mannose residue in the 1,1-linked disaccharide as mimetics of sialyl Lewis X tetrasaccharide in order to enhance binding affinity to selectins. (C) 1998 Elsevier Science Ltd. All rights reserved.
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页码：15781 / 15792
页数：12
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