Strategies for viral RNA stability: live long and prosper

被引：42

作者：

Dickson, Alexa M. ^{[1
]}

Wilusz, Jeffrey ^{[1
]}

机构：

[1] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

TRENDS IN GENETICS | 2011年 / 27卷 / 07期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; VIRUS-REPLICATION; BINDING-PROTEIN; LSM PROTEINS; ELEMENT; DECAY; MICRORNA; HOST; EXORIBONUCLEASE; TRANSLATION;

D O I：

10.1016/j.tig.2011.04.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Eukaryotic cells have a powerful RNA decay machinery that plays an important and diverse role in regulating both the quantity and the quality of gene expression. Viral RNAs need to successfully navigate around this cellular machinery to initiate and maintain a highly productive infection. Recent work has shown that viruses have developed a variety of strategies to accomplish this, including inherent RNA shields, hijacking host RNA stability factors, incapacitating the host decay machinery and changing the entire landscape of RNA stability in cells using virally encoded nucleases. In addition to maintaining the stability of viral transcripts, these strategies can also contribute to the regulation and complexity of viral gene expression as well as to viral RNA evolution.

引用

页码：286 / 293

页数：8

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