Tailoring nanocarriers for intracellular protein delivery

被引：483
作者：
Gu, Zhen [1 ,2 ,3 ]
Biswas, Anuradha [1 ,2 ]
Zhao, Muxun [1 ,2 ]
Tang, Yi [1 ,2 ,4 ]
机构：
[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Dept Mech & Aerosp Engn, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
来源：
CHEMICAL SOCIETY REVIEWS | 2011年 / 40卷 / 07期
关键词：
MESOPOROUS SILICA NANOPARTICLES; MEDIATED DELIVERY; IN-VIVO; FUNCTIONAL PROTEINS; HYDROGEL PARTICLES; CYTOSOLIC DELIVERY; CARBON NANOTUBES; MAMMALIAN-CELLS; QUANTUM DOTS; ANTIGEN;
D O I：
10.1039/c0cs00227e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering active forms of proteins to specific cells and organs. Intracellular protein delivery holds enormous promise for biological and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic diseases and imaging. This tutorial review surveys recent developments in intracellular protein delivery using various nanocarriers. Methods such as lipid-mediated colloidal systems, polymeric nanocarriers, inorganic systems and protein-mediated carriers are reviewed. Advantages and limitations of current strategies, as well as future opportunities and challenges are also discussed.
引用
收藏
页码：3638 / 3655
页数：18
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