Terahertz time-domain spectroscopy and imaging of artificial RNA

被引：189
作者：
Fischer, BM
Hoffmann, M
Helm, H
Wilk, R
Rutz, F
Kleine-Ostmann, T
Koch, M
Jepsen, PU
机构：
[1] Univ Freiburg, Freiburger Mat Res Ctr, Dept Mol & Opt Phys, D-79104 Freiburg, Germany
[2] Tech Univ Braunschweig, Inst Hochfrequenztech, D-38106 Braunschweig, Germany
[3] Tech Univ Denmark, Res Ctr COM, DK-2800 Lyngby, Denmark
来源：
OPTICS EXPRESS | 2005年 / 13卷 / 14期
关键词：
D O I：
10.1364/OPEX.13.005205
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
We use terahertz time-domain spectroscopy (THz-TDS) to measure the far-infrared dielectric function of two artificial RNA single strands, composed of polyadenylic acid (poly-A) and polycytidylic acid (poly-C). We find a significant difference in the absorption between the two types of RNA strands, and we show that we can use this difference to record images of spot arrays of the RNA strands. Under controlled conditions it is possible to use the THz image to distinguish between the two RNA strands. We discuss the requirements to sample preparation imposed by the lack of sharp spectral features in the absorption spectra. (C) 2005 Optical Society of America.
引用
收藏
页码：5205 / 5215
页数：11
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