Cellular effects of 5-formyluracil in DNA

被引：33
作者：
Bjelland, S
Ånensen, H
Knævelsrud, I
Seeberg, E
机构：
[1] Stavanger Univ Coll, Sch Sci & Technol, N-4091 Oslo, Norway
[2] Univ Oslo, Inst Med Microbiol, Dept Mol Biol, Natl Hosp, N-0027 Oslo, Norway
来源：
MUTATION RESEARCH-DNA REPAIR | 2001年 / 486卷 / 02期
关键词：
oxidative DNA damage; 5-formyluracil; 5-formyl-2 '-deoxyuridine;
D O I：
10.1016/S0921-8777(01)00085-4
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
5-Formyluracil is a major oxidation product of thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydro-guanine by exposure to gamma -irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage. (C) 2001 Elsevier Science B.V. All rights reserved.
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收藏
页码：147 / 154
页数：8
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