Cellular effects of 5-formyluracil in DNA

被引：33

作者：

Bjelland, S

Ånensen, H

Knævelsrud, I

Seeberg, E

机构：

[1] Stavanger Univ Coll, Sch Sci & Technol, N-4091 Oslo, Norway

[2] Univ Oslo, Inst Med Microbiol, Dept Mol Biol, Natl Hosp, N-0027 Oslo, Norway

来源：

MUTATION RESEARCH-DNA REPAIR | 2001年 / 486卷 / 02期

关键词：

oxidative DNA damage; 5-formyluracil; 5-formyl-2 '-deoxyuridine;

D O I：

10.1016/S0921-8777(01)00085-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

5-Formyluracil is a major oxidation product of thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydro-guanine by exposure to gamma -irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：147 / 154

页数：8

共 51 条

[1]

Alcantara R., 1965, PHOTOCHEM PHOTOBIOL, V4, P473, DOI [10.1111/j.1751-1097.1965.tb09762.x, DOI 10.1111/J.1751-1097.1965.TB09762.X]

[2]

ALCANTARA R, 1965, PHOTOCHEM PHOTOBIOL, V4, P465

[3] Mutations induced by 5-formyl-2′-deoxyuridine in Escherichia coli include base substitutions that can arise from mispairs of 5-formyluracil with guanine, cytosine and thymine [J].