Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials

被引:54
作者
Garcia-Gallego, Sandra [1 ,2 ]
Franci, Gianluigi [3 ,4 ]
Falanga, Annarita [5 ]
Gomez, Rafael [1 ,2 ]
Folliero, Veronica [3 ]
Galdiero, Stefania [4 ,5 ,6 ]
Javier de la Mata, Francisco [1 ,2 ]
Galdiero, Massimiliano [3 ,4 ]
机构
[1] Univ Alcala, Organ & Inorgan Chem Dept, Campus Univ, E-28871 Alcala De Henares, Spain
[2] Res Ctr Bioengn Biomat & Nanomed CIBER BBN, Madrid 28029, Spain
[3] II Univ Naples, Dept Expt Med, Via Costantinopoli 16, I-80138 Naples, Italy
[4] Univ Naples Federico II, Interuniv Res Ctr Bioact Peptides CiRPEB, Via Mezzocannone 16, I-80134 Naples, Italy
[5] Univ Naples Federico II, Dept Pharm, Via Mezzocannone 16, I-80134 Naples, Italy
[6] Loyola Univ Chicago, John Felice Rome Ctr, Via Massimi 114, I-00136 Rome, Italy
关键词
dendrimers; structure; preparation; delivery; antimicrobial; antibacterial; antiviral; antiparasitic; POLY(PROPYLENE IMINE) DENDRIMERS; CATIONIC CARBOSILANE DENDRIMERS; HEAT-LABILE ENTEROTOXIN; POLY(AMIDOAMINE) DENDRIMERS; ESCHERICHIA-COLI; GENE DELIVERY; IN-VITRO; POLYAMIDOAMINE DENDRIMERS; CAPILLARY-ELECTROPHORESIS; PHOSPHORUS DENDRIMERS;
D O I
10.3390/molecules22101581
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In recent years innovative nanostructures are attracting increasing interest and, among them, dendrimers have shown several fields of application. Dendrimers can be designed and modified in plentiful ways giving rise to hundreds of different molecules with specific characteristics and functionalities. Biomedicine is probably the field where these molecules find extraordinary applicability, and this is probably due to their multi-valency and to the fact that several other chemicals can be coupled to them to obtain desired compounds. In this review we will describe the different production strategies and the tools and technologies for the study of their characteristics. Finally, we provide a panoramic overview of their applications to meet biomedical needs, especially their use as novel antimicrobials.
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页数:29
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