Quantification of Daily-Living Gait Quantity and Quality Using a Wrist-Worn Accelerometer in Huntington's Disease

被引：16

作者：

Keren, Karin ^{[1
,2
]}

Busse, Monica ^{[3
]}

Fritz, Nora E. ^{[4
,5
]}

Muratori, Lisa M. ^{[6
,7
]}

Gazit, Eran ^{[1
]}

Hillel, Inbar ^{[1
]}

Scheinowitz, Micky ^{[8
]}

Gurevich, Tanya ^{[9
,10
]}

Inbar, Noit ^{[9
]}

Omer, Nurit ^{[9
,10
]}

Hausdorff, Jeffrey M. ^{[1
,10
,11
,12
,13
]}

Quinn, Lori ^{[3
,14
]}

机构：

[1] Tel Aviv Sourasky Med Ctr, Neurol Inst, Ctr Study Movement Cognit & Mobil, Tel Aviv, Israel

[2] Tel Aviv Univ, Dept Biomed Engn, Tel Aviv, Israel

[3] Cardiff Univ, Ctr Trials Res, Cardiff, Wales

[4] Wayne State Univ, Dept Hlth Care Sci, Detroit, MI 48202 USA

[5] Wayne State Univ, Dept Neurol, Detroit, MI 48202 USA

[6] SUNY Stony Brook, Sch Hlth Technol & Management, Dept Phys Therapy, Stony Brook, NY USA

[7] George Huntingtons Inst, Munster, Germany

[8] Tel Aviv Univ, Sch Publ Hlth, Tel Aviv, Israel

[9] Tel Aviv Med Ctr & Sch Med, Movement Disorders Unit, Tel Aviv, Israel

[10] Tel Aviv Univ, Sackler Sch Med & Sagol, Sch Neurosci, Tel Aviv, Israel

[11] Tel Aviv Univ, Dept Phys Therapy, Sackler Fac Med, Tel Aviv, Israel

[12] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[13] Rush Univ, Med Ctr, Dept Orthopaed Surg, Chicago, IL 60612 USA

[14] Columbia Univ, Teachers Coll, Dept Biobehav Sci, New York, NY 10027 USA

来源：

FRONTIERS IN NEUROLOGY | 2021年 / 12卷

关键词：

accelerometry; physical activity; digital markers; inertial measurements; chorea; PARKINSONS-DISEASE; SENSOR; BALANCE;

D O I：

10.3389/fneur.2021.719442

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Huntington's disease (HD) leads to altered gait patterns and reduced daily-living physical activity. Accurate measurement of daily-living walking that takes into account involuntary movements (e.g. chorea) is needed. Objective: To evaluate daily-living gait quantity and quality in HD, taking into account irregular movements. Methods: Forty-two individuals with HD and fourteen age-matched non-HD peers completed clinic-based assessments and a standardized laboratory-based circuit of functional activities, wearing inertial measurement units on the wrists, legs, and trunk. These activities were used to train and test an algorithm for the automated detection of walking. Subsequently, 29 HD participants and 22 age-matched non-HD peers wore a tri-axial accelerometer on their non-dominant wrist for 7 days. Measures included gait quantity (e.g., steps per day), gait quality (e.g., regularity) metrics, and percentage of walking bouts with irregular movements. Results: Measures of daily-living gait quantity including step counts, walking time and bouts per day were similar in HD participants and non-HD peers (p > 0.05). HD participants with higher clinician-rated upper body chorea had a greater percentage of walking bouts with irregular movements compared to those with lower chorea (p = 0.060) and non-HD peers (p < 0.001). Even after accounting for irregular movements, within-bout walking consistency was lower in HD participants compared to non-HD peers (p < 0.001), while across-bout variability of these measures was higher (p < 0.001). Many of the daily-living measures were associated with disease-specific measures of motor function. Conclusions: Results suggest that a wrist-worn accelerometer can be used to evaluate the quantity and quality of daily-living gait in people with HD, while accounting for the influence of irregular (choreic-like) movements, and that gait features related to within- and across-bout consistency markedly differ in individuals with HD and non-HD peers.

引用

页数：10

共 35 条

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