Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

被引：354
作者：
Butterfield, DA
Kanski, J
机构：
[1] Univ Kentucky, Ctr Membrane Sci, Dept Chem, Lexington, KY 40506 USA
[2] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40506 USA
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2001年 / 122卷 / 09期
关键词：
age-related neurodegenerative disorders aggregated proteins; brain protein oxidation;
D O I：
10.1016/S0047-6374(01)00249-4
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Protein oxidation, one of a number of brain biomarkers of oxidative stress, is increased in several age-related neurodegenerative disorders or animal models thereof including Alzheimer's disease, Huntington's disease, prion disorders, such as Creutzfeld-Jakob disease, and alpha -synuclein disorders, such as Parkinson's disease and frontotemporal dementia. Each of these neurodegenerative disorders is associated with aggregated proteins in brain. However, the relationship among protein oxidation. protein aggregation. and neurodegeneration remain unclear. The current rapid progress in elucidation of mechanisms of protein oxidation in neuronal loss should provide further insight into the importance of Free radical oxidative stress in these neurodegenerative disorders. (C) 2001 Elsevier Science Ieeland Ltd. All rights reserved.
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收藏
页码：945 / 962
页数：18
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