Termination of stem cell maintenance in Arabidopsis floral meristems by interactions between WUSCHEL and AGAMOUS

被引：499

作者：

Lenhard, M ^{[1
]}

Bohnert, A ^{[1
]}

Jürgens, G ^{[1
]}

Laux, T ^{[1
]}

机构：

[1] Univ Tubingen, ZMBP Entwicklungsgenet, D-72076 Tubingen, Germany

来源：

CELL | 2001年 / 105卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(01)00390-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Floral meristems and shoot apical meristems (SAMs) are homologous, self-maintaining stem cell systems. Unlike SAMs, floral meristems are determinate, and stem cell maintenance is abolished once all floral organs are initiated. to investigate the underlying regulatory mechanisms, we analyzed the interactions between WUSCHEL (WUS), which specifies stem cell identity, and AGAMOUS (AG), which is required for floral determinacy. Our results show that repression of WUS by AG is essential for terminating the floral meristem and that WUS can induce AG expression in developing flowers. Together, this suggests that floral determinacy depends on a negative autoregulatory mechanism involving WUS and AG, which terminates stem cell maintenance.

引用

页码：805 / 814

页数：10

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