Rhein promotes TRAIL-induced apoptosis in bladder cancer cells by up-regulating DR5 expression

被引：7
|
作者：
Ma, Liang [1 ,2 ]
Wei, Hong-Ling [3 ,4 ]
Wang, Ke-Jie [3 ,4 ]
Meng, Xiang-Yu [3 ,4 ]
Ni, Sai-Qi [3 ,4 ]
Zhou, Cheng [5 ]
Li, Yi [6 ]
Yu, Rui [1 ]
Ma, Qi [2 ,3 ,4 ,5 ]
机构：
[1] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Ningbo Hosp 1, Comprehens Urogenital Canc Ctr, Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[3] Ningbo Univ, Ningbo Hosp 1, Translat Res Lab Urol, Key Lab Ningbo City,Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[4] Ningbo Clin Res Ctr Urol Dis, Ningbo 315010, Zhejiang, Peoples R China
[5] Ningbo Univ, Ningbo Hosp 1, Dept Urol, Affiliated Hosp, Ningbo 315010, Zhejiang, Peoples R China
[6] Zhejiang Univ, Affiliated Hosp 2, Dept Urol, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China
来源：
AGING-US | 2022年 / 14卷 / 16期
关键词：
bladder cancer; drug resistance; Rhein; TRAIL; DR5; DEATH RECEPTORS; TNF-FAMILY; KAPPA-B; RESISTANCE; LIGAND; SUPPRESSION; STATISTICS; MECHANISMS; CARCINOMA;
D O I：
10.18632/aging.204236
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) combined with sensitizer is a potential method to reverse TRAIL-resistance in tumor cells. Rhein (RH) is a monomer extracted from Chinese herbs that has been reported to show anti-tumor effects in a variety of tumor cells, but the role of RH in TRAIL-induced anti-tumor effects in bladder cancer cells has not been reported. In this study, we found that the combined treatment of a non-toxic concentration of RH with TRAIL significantly inhibited the proliferation and induced apoptosis in both TRAIL sensitive and resistant bladder cancer cell lines. Furthermore, we found that RH promoted bladder cancer cell apoptosis by up-regulating DR5 expression. Our findings provide potential value in the clinical treatment of bladder cancer.
引用
收藏
页码：6642 / 6655
页数：14
相关论文
共 50 条
  • [41] Diclofenac sensitizes melanoma cells to TRAIL-induced apoptosis through upregulation of TRAIL-R2/DR5 in the resistant melanoma cells
    Strauss, M. Vazquez
    Stingl, G.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2014, 134 : S92 - S92
  • [42] MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation
    Lim, Sung-Chul
    Hanz, Song Ly
    KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2017, 21 (04): : 397 - 405
  • [43] A novel, soluble compound, C25, sensitizes to TRAIL-induced apoptosis through upregulation of DR5 expression
    James, Michael A.
    Seibel, William L.
    Kupert, Elena
    Hu, Xiao X.
    Potharla, Vishwakanth Y.
    Anderson, Marshall W.
    ANTI-CANCER DRUGS, 2015, 26 (05) : 518 - 530
  • [44] Sensitivity of prostate cells to TRAIL-induced apoptosis increases with tumor progression:: DR5 and caspase 8 are key players
    Hesry, Vincent
    Piquet-Pellorce, Claire
    Travert, Marion
    Donaghy, Ludovic
    Jegou, Bernard
    Patard, Jean-Jacques
    Guillaudeux, Thierry
    PROSTATE, 2006, 66 (09): : 987 - 995
  • [45] Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells
    Shunchao Yan
    Xiujuan Qu
    Chong’an Xu
    Zhitu Zhu
    Lingyun Zhang
    Ling Xu
    Na Song
    Yuee Teng
    Yunpeng Liu
    Journal of Cancer Research and Clinical Oncology, 2012, 138 : 1279 - 1289
  • [46] Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells
    Yan, Shunchao
    Qu, Xiujuan
    Xu, Chong'an
    Zhu, Zhitu
    Zhang, Lingyun
    Xu, Ling
    Song, Na
    Teng, Yuee
    Liu, Yunpeng
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2012, 138 (08) : 1279 - 1289
  • [47] Oridonin enhances TRAIL-induced apoptosis through GALNT14-mediated DR5 glycosylation
    Jeon, Mi-Yeon
    Seo, Seung Un
    Woo, Seon Min
    Min, Kyoung-jin
    Byun, Hee Sun
    Hur, Gang Min
    Kang, Sun Chul
    Kwon, Taeg Kyu
    BIOCHIMIE, 2019, 165 : 108 - 114
  • [48] Selective targeting of DR5 circumvents resistance of MG-63 osteosarcoma to trail-induced apoptosis
    Locklin, RM
    Federici, E
    Espina, B
    Hulley, P
    Russell, RGG
    Shipman, CM
    BONE, 2006, 38 (03) : S13 - S14
  • [49] FSH inhibits ovarian cancer cell apoptosis by up-regulating survivin and down-regulating PDCD6 and DR5
    Huang, Yan
    Jin, Hongyan
    Liu, Yingtao
    Zhou, Jiayi
    Ding, Jingxin
    Cheng, Kwai Wa
    Yu, Yinhua
    Feng, Youji
    ENDOCRINE-RELATED CANCER, 2011, 18 (01) : 13 - 26
  • [50] PPARγ ligands enhance TRAIL-induced apoptosis through DR5 upregulation and c-FLIP downregulation in human lung cancer cells
    Zou, Wei
    Liu, Xiangguo
    Yue, Ping
    Khuri, Fadlo R.
    Sun, Shi-Yong
    CANCER BIOLOGY & THERAPY, 2007, 6 (01) : 99 - 106
12345