Drug Resistance Mutations in Drug-Naive HIV Type 1 Subtype C-Infected Individuals from Rural Malawi

被引：7

作者：

Bansode, Vijay

Drebert, Zuzanna J.

Travers, Simon A. A. ^{[2
]}

Banda, Emmanuel ^{[3
]}

Molesworth, Anna ^{[3
,4
]}

Crampin, Amelia ^{[3
,4
]}

Ngwira, Bagrey ^{[3
,4
]}

French, Neil ^{[3
,4
]}

Glynn, Judith R. ^{[3
]}

McCormack, Grace P. ^{[1
]}

机构：

[1] Natl Univ Ireland, Mol Evolut & Systemat Lab, Dept Zool, Martin Ryan Inst,Sch Nat Sci, Galway, Ireland

[2] Univ Western Cape, S African Natl Bioinformat Inst, ZA-7535 Bellville, South Africa

[3] Karonga Prevent Study, Chilumba, Malawi

[4] London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1, England

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2011年 / 27卷 / 04期

基金：

英国惠康基金; 爱尔兰科学基金会;

关键词：

REVERSE-TRANSCRIPTASE; PROTEASE;

D O I：

10.1089/aid.2010.0203

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.

引用

页码：439 / 444

页数：6

共 15 条

[1] Resistance mutational analysis of HIV type 1 subtype C among rural South African drug-naive patients prior to large-scale availability of antiretrovirals [J].