New nanoscale pulsatile drug delivery system

A new type of photocontrolled, liposomal drug delivery system with a average diameter of 99.7 nm that can achieve zero-order, multi-pulsatile release, and sustained release was described. The cytotoxicity of this drag delivery system was examined using NIH3T3 cells. The synthetic phototrigger decreases the spontaneous release of drug and increases the stability of liposomes beyond what have been previously reported. The amount of drug released from liposomes can be controlled by maintaining the concentration of the cis isomer of AB lipid 1 by UV irradiation, and the release rate can be controlled by altering the incorporation ratio of AB lipid 1.