Treatment of tubal ectopic pregnancy by methotrexate

被引：6

作者：

Lesavre, M. ^{[1
]}

Curinier, S. ^{[2
]}

Capmas, P. ^{[1
]}

Rabischong, B. ^{[2
]}

Fernandez, H. ^{[1
]}

机构：

[1] CHU Bicetre, Serv Gynecol Obstet, F-94276 Le Kremlin Bicetre, France

[2] CHU Estaing, Serv Gynecol Obstet, F-63003 Clermont Ferrand, France

来源：

JOURNAL DE GYNECOLOGIE OBSTETRIQUE ET BIOLOGIE DE LA REPRODUCTION | 2015年 / 44卷 / 03期

关键词：

Ectopic pregnancy; Methotrexate; Fertility; Economic cost; HUMAN CHORIONIC-GONADOTROPIN; SINGLE-DOSE METHOTREXATE; SYSTEMIC METHOTREXATE; RANDOMIZED-TRIAL; EXPECTANT MANAGEMENT; LAPAROSCOPIC SALPINGOSTOMY; PREDICTIVE SCORE; WOMEN; FAILURE; SUCCESS;

D O I：

10.1016/j.jgyn.2014.12.013

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives. -To make a literature analyse about methotrexate as a treatment of tubal ectopic pregnancy. Materials and methods. -We made a PubMed research and found articles, randomized control studies, systematic revues and meta-analyses of the Cochrane Database about ectopic pregnancies treated by methotrexate. We made a summary of these articles. Results. -Methotrexate can be used as a treatment of tubal ectopic pregnancy with hCG <5000 Ul /L and expectative is an option if hCG level is lower than 1500 Ul /L. Medical treatment by rnethotrexate seems to be less effective than surgical salpingotomy but the rate of recurrence and the rate of intra-uterin pregnancy are similar regardless of the treatment chosen. Fertility seems to be the same after treatment by methotrexate. Economically, methotrexate is less expensive than the surgical management (laparoscopy). Conclusion. -Methotrexate can be used as a treatment of tubal ectopic pregnancies if every criterions of safety are gathered. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：212 / 219

页数：8

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