Fabrication of fibrous silica sponges by self-assembly electrospinning and their application in tissue engineering for three-dimensional tissue regeneration

被引:50
作者
Mi, Hao-Yang [1 ,2 ,3 ]
Jing, Xin [1 ,3 ]
Napiwocki, Brett N. [3 ,4 ]
Li, Zhu-Tong [3 ]
Turng, Lih-Sheng [2 ,3 ]
Huang, Han-Xiong [1 ]
机构
[1] South China Univ Technol, Dept Ind Equipment & Control Engn, Guangzhou 510640, Guangdong, Peoples R China
[2] Univ Wisconsin, Dept Mech Engn, Madison, WI 53706 USA
[3] Univ Wisconsin, Wisconsin Inst Discovery, Madison, WI 53715 USA
[4] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53706 USA
基金
中国国家自然科学基金;
关键词
Self assembly; Electrospinning; 3D silica fiber; Tissue engineering; Cell penetration; NANOFIBERS; FIBERS; SCAFFOLDS; MEMBRANE; NETWORKS; BEHAVIOR; WATER; JETS;
D O I
10.1016/j.cej.2017.09.020
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Fabrication of highly porous, three-dimensional (3D) scaffolds with biomimicking microstructures for tissue engineering has received extensive attention lately. Although several studies have used silica as a filler material in various polymeric scaffold matrices for tissue engineering, there are no reports of 3D scaffolds fabricated solely with silica. In this study, we developed a method to fabricate fibrous silica sponges using a tetraethyl orthosilicate (TEOS)/polyvinyl alcohol (PVA) solution via self-assembly electrospinning and subsequent calcination. We then evaluated its potential application in tissue engineering. A detailed mechanism study revealed that appropriate crosslinking between hydrolyzed TEOS and PVA was the key to inducing 3D fiber stacking. The prepared silica sponges had a bulk density of 16 mg/cm(3), a surface area of 6.45 m(2)/g, and a porosity of 98%, which endowed them with super-high absorbability. Cell culture results with 3T3 fibroblasts confirmed that the cells interacted strongly with the 3D silica fibers, showing a higher viability and proliferation rate than on 2D silica membranes, and that the cells migrated into the inner area of the sponge rapidly, indicating these silica sponges have potential to be used for 3D tissue regeneration.
引用
收藏
页码:652 / 662
页数:11
相关论文
共 50 条
[1]   Three-Dimensional Electrospun Alginate Nanofiber Mats via Tailored Charge Repulsions [J].
Bonino, Christopher A. ;
Efimenko, Kirill ;
Jeong, Sung In ;
Krebs, Melissa D. ;
Alsberg, Eben ;
Khan, Saad A. .
SMALL, 2012, 8 (12) :1928-1936
[2]   Formation and self-assembly of 3D nanofibrous networks based on oppositely charged jets [J].
Chang, Guoqing ;
Zhu, Xuefeng ;
Li, Aike ;
Kan, Weiwei ;
Warren, Roseanne ;
Zhao, Ruiguo ;
Wang, Xiaoliang ;
Xue, Gi ;
Shen, Jianyi ;
Lin, Liwei .
MATERIALS & DESIGN, 2016, 97 :126-130
[3]   Electrospinning and solution properties of Nafion and poly(acrylic acid) [J].
Chen, Hong ;
Snyder, Joshua D. ;
Elabd, Yossef A. .
MACROMOLECULES, 2008, 41 (01) :128-135
[4]   Superelastic, superabsorbent and 3D nanofiber-assembled scaffold for tissue engineering [J].
Chen, Weiming ;
Ma, Jun ;
Zhu, Lei ;
Morsi, Yosry ;
EI-Hamshary, Hany ;
Al-Deyab, Salem S. ;
Mo, Xiumei .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2016, 142 :165-172
[5]   Mullite-Nickel Magnetic Nanocomposite Fibers Obtained from Electrospinning Followed by Thermal Reduction [J].
Chen, Zhaoxi ;
Gu, Yu ;
Aprelev, Pavel ;
Kornev, Konstantin ;
Luzinov, Igor ;
Chen, Jie ;
Peng, Fei .
JOURNAL OF THE AMERICAN CERAMIC SOCIETY, 2016, 99 (05) :1504-1511
[6]   Silica nanofibers from electrospinning/sol-gel process [J].
Choi, SS ;
Lee, SG ;
Im, SS ;
Kim, SH ;
Joo, YL .
JOURNAL OF MATERIALS SCIENCE LETTERS, 2003, 22 (12) :891-893
[7]   Polydopamine Inter-Fiber Networks: New Strategy for Producing Rigid, Sticky, 3D Fluffy Electrospun Fibrous Polycaprolactone Sponges [J].
Choi, Wuyong ;
Lee, Slgirim ;
Kim, Seung-Hyun ;
Jang, Jae-Hyung .
MACROMOLECULAR BIOSCIENCE, 2016, 16 (06) :824-835
[8]   Silica coating of the pore walls of a microporous polycaprolactone membrane to be used in bone tissue engineering [J].
Demirdogen, B. ;
Plazas Bonilla, C. E. ;
Trujillo, S. ;
Perilla, J. E. ;
Elcin, A. E. ;
Elcin, Y. M. ;
Gomez Ribelles, J. L. .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (09) :3229-3236
[9]   Electrospun Multiscale Structured Membrane for Efficient Water Collection and Directional Transport [J].
Du, Ming ;
Zhao, Yong ;
Tian, Ye ;
Li, Kan ;
Jiang, Lei .
SMALL, 2016, 12 (08) :1000-1005
[10]   Ultralight, Soft Polymer Sponges by Self-Assembly of Short Electrospun Fibers in Colloidal Dispersions [J].
Duan, Gaigai ;
Jiang, Shaohua ;
Jerome, Valerie ;
Wendorff, Joachim H. ;
Fathi, Amir ;
Uhm, Jaqueline ;
Altstaedt, Volker ;
Herling, Markus ;
Breu, Josef ;
Freitag, Ruth ;
Agarwal, Seema ;
Greiner, Andreas .
ADVANCED FUNCTIONAL MATERIALS, 2015, 25 (19) :2850-2856