The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists

被引：1889

作者：

Huang, Da Wei ^{[1
]}

Sherman, Brad T. ^{[1
]}

Tan, Qina ^{[1
]}

Collins, Jack R.

Alvord, W. Gregory ^{[2
]}

Roayaei, Jean ^{[2
]}

Stephens, Robert

Baseler, Michael W. ^{[1
]}

Lane, H. Clifford ^{[3
]}

Lempicki, Richard A. ^{[1
]}

机构：

[1] NCI, Lab Immunopathogenesis & Bioinformat, Clin Serv Program, SAIC Frederick Inc, Frederick, MD 21702 USA

[2] NCI, Comp Stat Serv, Data Management Serv, Frederick, MD 21702 USA

[3] NIH, NIAID, Immunoregulat Lab, Bethesda, MD 20892 USA

来源：

GENOME BIOLOGY | 2007年 / 8卷 / 09期

关键词：

D O I：

10.1186/gb-2007-8-9-r183

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The DAVID Gene Functional Classification Tool http://david.abcc.ncifcrf.gov uses a novel agglomeration algorithm to condense a list of genes or associated biological terms into organized classes of related genes or biology, called biological modules. This organization is accomplished by mining the complex biological co-occurrences found in multiple sources of functional annotation. It is a powerful method to group functionally related genes and terms into a manageable number of biological modules for efficient interpretation of gene lists in a network context.

引用

页数：16

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