The Blood-Brain Barrier: Much More Than a Selective Access to the Brain

被引：20

作者：

Sanchez-Cano, Fredy ^{[1
]}

Hernandez-Kelly, Luisa C. ^{[1
]}

Ortega, Arturo ^{[1
]}

机构：

[1] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Lab Neurotoxicol, Dept Toxicol, Av IPN 2508, San Pedro Zacatenco 07300, Mexico

来源：

NEUROTOXICITY RESEARCH | 2021年 / 39卷 / 06期

关键词：

Blood-brain barrier; Endothelial cell; Astrocytes; Pericytes; Xenobiotics; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CAPILLARY ENDOTHELIAL-CELLS; JUNCTION PROTEIN EXPRESSION; CENTRAL-NERVOUS-SYSTEM; AMYLOID-BETA; OXIDATIVE STRESS; ALZHEIMERS-DISEASE; TIGHT JUNCTIONS; COCULTURE MODEL; GROWTH-FACTOR;

D O I：

10.1007/s12640-021-00431-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The blood-brain barrier is a dynamic structure, collectively referred to as the neurovascular unit. It is responsible for the exchange of blood, oxygen, ions, and other molecules between the peripheral circulation and the brain compartment. It is the main entrance to the central nervous system and as such critical for the maintenance of its homeostasis. Dysfunction of the blood-brain barrier is a characteristic of several neurovascular pathologies. Moreover, physiological changes, environmental factors, nutritional habits, and psychological stress can modulate the tightness of the barrier. In this contribution, we summarize our current understanding of structure and function of this important component of the brain. We also describe the neurological deficits associated with its damage. A special emphasis is placed in the effect of the exposure to xenobiotics and pollutants in the permeability of the barrier. Finally, current protective strategies as well as the culture models to study this fascinating structure are discussed.

引用

页码：2154 / 2174

页数：21

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