Quasispecies dynamics and RNA virus extinction

被引：88
作者：
Domingo, E [1 ]
Escarmís, C
Lázaro, E
Manrubia, SC
机构：
[1] Univ Autonoma Madrid, Consejo Super Invest Cient, Ctr Biol Mol Severo Ochoa, CSIC UAM, E-28049 Madrid, Spain
[2] CSIC, INTA, Ctr Astrobiol, Madrid 28850, Spain
[3] Ctr Invest San Anim INIA, Madrid 28130, Spain
来源：
VIRUS RESEARCH | 2005年 / 107卷 / 02期
关键词：
foot-and-mouth disease virus; 5-fluorouracil; 5-azacytidine; mutation;
D O I：
10.1016/j.virusres.2004.11.003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The extinction of foot-and-mouth disease Virus (FMDV) is strongly influenced by mutation rates, types of mutations, relative viral fitness and virus population regimens during infection. Here we review experimental results and theoretical models that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related FMDV clones subjected to serial bottleneck events. The results suggest procedures to master key parameters to develop effective antiviral strategies based on virus entry into error catastrophe. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：129 / 139
页数：11
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