Mappain, a new cytotoxic prenylated stilbene from Macaranga mappa

被引：25

作者：

van der Kaaden, JE

Hemscheidt, TK

Mooberry, SL

机构：

[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA

[2] Univ Hawaii Manoa, Nat Prod Program, Canc Res Ctr Hawaii, Honolulu, HI 96813 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 01期

关键词：

D O I：

10.1021/np000265r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new prenylated stilbene, mappain (1), was isolated from leaves of Macaranga mappa by bioassay-guided fractionation. The structure was established by application of spectroscopic methods. Mappain is cytotoxic but it appears to be a poor substrate for P-glycoprotein-mediated transport because it is equally potent and effective against the drug-sensitive SK-OV-3 and drug-resistant SKVLB-1 ovarian cancer cell lines, exhibiting an IC50 value of 1.3 muM in both cases.

引用

页码：103 / 105

页数：3

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