Decreased expression of the metastasis suppressor gene KAI1 in gastric cancer

被引：46

作者：

Hinoda, Y ^{[1
]}

Adachi, Y ^{[1
]}

Takaoka, A ^{[1
]}

Mitsuuchi, H ^{[1
]}

Satoh, Y ^{[1
]}

Itoh, F ^{[1
]}

Kondoh, Y ^{[1
]}

Imai, K ^{[1
]}

机构：

[1] Sapporo Med Univ, Dept Internal Med 1, Chuo Ku, Sapporo, Hokkaido 0608543, Japan

来源：

CANCER LETTERS | 1998年 / 129卷 / 02期

关键词：

metastasis suppressor gene; KAI1; gastric cancer; intestinal metaplasia;

D O I：

10.1016/S0304-3835(98)00112-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

KAI1 was immunohistochemically detected in the lower part of fundic glands and intestinal metaplasia in non-cancerous gastric tissues, while only 11.0% (8/73) of cancerous tissues were shown to be positive. The relationship between Various clinicopathological characteristics of patients with gastric cancer and KAI1 expression in their tumors was then analyzed to reveal that the incidence of positivity was 16.6% (8/48) of patients with stage Ia-ma and 0% (0/25) of patients with stage IIIb-IVb (P < 0.05) and that the incidence of peritoneal or hepatic metastasis tended to be lower in KAI1-positive tumors than in negative ones. These results suggest that decreased KAI1 expression may be related to the progression of gastric cancer. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：229 / 234

页数：6

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