Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae

被引：33

作者：

Ishihara, K

Murata, M

Kaneniwa, M

Saito, H

Shinohara, K

Maeda-Yamamoto, M

机构：

[1] Natl Res Inst Fisheries Sci, Marine Biochem Div, Kanazawa Ku, Yokohama, Kanagawa 2368648, Japan

[2] Natl Food Res Inst, Ibaraki, Osaka 3050856, Japan

[3] Natl Res Inst Vegetables Ornamental Plants & Tea, Shizuoka 4288501, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1998年 / 62卷 / 07期

关键词：

mast cell; octadecatetraenoic acid; hexadecatetraenoic acid; icosanoid; marine alga;

D O I：

10.1271/bbb.62.1412

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of two polyunsaturated fatty acids, 18:4n-3 and 16:4n-3 purified from the marine algae, Undaria pinnatifida and Ulva pertusa, on icosanoid production in MC/9 mouse mast cells were assessed. Both fatty acids suppressed the production of leukotriene B-4 (LTB4), leukotriene C-4 (LTC4), and 5-hydroxyeicosatetraenoic acid (5-HETE). The order of the suppressive activity for the two marine algae-derived fatty acids and three other common polyunsaturated fatty acids was as follows; 22:4n3 = 18:3n-3 = 18:3n-3 > 20:5n-3 = 16:4n-3 for LTB4; 22:6n-3 = 18:4n-3 = 18:3n-3 > 16:4n-3 > 20:5n-3 (no suppression) for LTC4; 22:6n-3 = 18:4n-3 > 18:3n-3 > 20:5n-3 = 16:4n-3 for 5-HETE.

引用

页码：1412 / 1415

页数：4

共 17 条

[1]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[2] COMPARISON OF THE METABOLISM OF ALPHA-LINOLENIC ACID AND ITS DELTA-6 DESATURATION PRODUCT, STEARIDONIC ACID, IN CULTURED NIH-3T3 CELLS [J].