Interactions between Traumatic Brain Injury and Frontotemporal Degeneration

被引：42

作者：

Deutsch, Mariel B. ^{[1
,3
]}

Mendez, Mario F. ^{[1
,2
,3
]}

Teng, Edmond ^{[1
,3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[3] Vet Affairs Greater Los Angeles Healthcare Syst, Los Angeles, CA 90073 USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2015年 / 39卷 / 3-4期

关键词：

Brain injuries; Frontotemporal degeneration; Frontotemporal dementia; Frontotemporal lobar degeneration; Primary progressive aphasia; Neuropsychological features in subjects with dementia; ENVIRONMENTAL RISK-FACTORS; DATA SET UDS; HEAD-INJURY; FUNCTIONAL-ACTIVITIES; CLINICAL PHENOTYPE; LOBAR DEGENERATION; ALZHEIMERS-DISEASE; DEMENTIA;

D O I：

10.1159/000369787

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: Prior work in smaller cohorts suggests that traumatic brain injury (TBI) may be a risk factor for frontotemporal degeneration (FTD). We sought to confirm and extend these results using the National Alzheimer's Coordinating Center Uniform Data Set. Methods: We compared the TBI prevalence between FTD subjects and matched normal controls. Indices of cognitive, behavioral, functional, and global dementia severity were compared between FTD subjects with and without prior TBI. Results: Remote TBI with extended loss of consciousness (TBI-ext) was more common in individuals with FTD than in controls (OR: 1.67; 95% CI: 1.004-2.778). With TBI-ext, less functional and global impairment was seen in the behavioral variant of FTD, but more behavioral pathology was seen in the semantic variant. Conclusion: TBI may increase the FTD risk and influence clinical symptomatology and severity in FTD sub-types. (C) 2014 S. Karger AG, Basel

引用

页码：143 / 153

页数：11

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