Predicting Influenza H3N2 Vaccine Efficacy From Evolution of the Dominant Epitope

被引:24
作者
Bonomo, Melia E. [1 ,2 ]
Deem, Michael W. [1 ,2 ,3 ]
机构
[1] Rice Univ, Dept Phys & Astron, Houston, TX USA
[2] Rice Univ, Ctr Theoret Biol Phys, Houston, TX USA
[3] Rice Univ, Dept Bioengn, Houston, TX USA
基金
美国国家科学基金会;
关键词
influenza; influenza vaccine; vaccine efficacy; p(epitope); antigenic distance; VIRUSES;
D O I
10.1093/cid/ciy323
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We predict vaccine efficacy with a measure of antigenic distance between influenza A(H3N2) and vaccine viruses based on amino acid substitutions in the dominant epitope. In 2016-2017, our model predicts 19% efficacy compared with 20% observed. This tool assists candidate vaccine selection by predicting human protection against circulating strains.
引用
收藏
页码:1129 / 1131
页数:3
相关论文
共 13 条
  • [1] [Anonymous], 2016, Wkly Epidemiol Rec, V91, P121
  • [2] Sequence space localization in the immune system response to vaccination and disease
    Deem, MW
    Lee, HY
    [J]. PHYSICAL REVIEW LETTERS, 2003, 91 (06) : 1 - 068101
  • [3] Flannery B, 2017, MMWR-MORBID MORTAL W, V66, P167, DOI 10.15585/mmwr.mm6606a3
  • [4] Influenza Hemagglutinin and Neuraminidase Membrane Glycoproteins
    Gamblin, Steven J.
    Skehel, John J.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (37) : 28403 - 28409
  • [5] Predicting antigenic variants of influenza A/H3N2 viruses
    Lee, MS
    Chen, JSE
    [J]. EMERGING INFECTIOUS DISEASES, 2004, 10 (08) : 1385 - 1390
  • [6] Influenza evolution and H3N2 vaccine effectiveness, with application to the 2014/2015 season
    Li, Xi
    Deem, Michael W.
    [J]. PROTEIN ENGINEERING DESIGN & SELECTION, 2016, 29 (08) : 309 - 315
  • [7] The characteristics and antigenic properties of recently emerged subclade 3C.3a and 3C.2a human influenza A(H3N2) viruses passaged in MDCK cells
    Lin, Yipu
    Wharton, Stephen A.
    Whittaker, Lynne
    Dai, Mian
    Ermetal, Burcu
    Lo, Janice
    Pontoriero, Andrea
    Baumeister, Elsa
    Daniels, Rodney S.
    McCauley, John W.
    [J]. INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2017, 11 (03) : 263 - 274
  • [8] Low 2012-13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses
    Skowronski, Danuta M.
    Janjua, Naveed Z.
    De Serres, Gaston
    Sabaiduc, Suzana
    Eshaghi, Alireza
    Dickinson, James A.
    Fonseca, Kevin
    Winter, Anne-Luise
    Gubbay, Jonathan B.
    Krajden, Mel
    Petric, Martin
    Charest, Hugues
    Bastien, Nathalie
    Kwindt, Trijntje L.
    Mahmud, Salaheddin M.
    Van Caeseele, Paul
    Li, Yan
    [J]. PLOS ONE, 2014, 9 (03):
  • [9] Variable efficacy of repeated annual influenza vaccination
    Smith, DJ
    Forrest, S
    Ackley, DH
    Perelson, AS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (24) : 14001 - 14006
  • [10] The Crick Worldwide Influenza Centre, REP PREP WHO ANN CON