Tumorigenicity of pluripotent stem cells: biological insights from molecular imaging

被引：75
作者：
Kooreman, Nigel G. [1 ,2 ,3 ]
Wu, Joseph C. [1 ,2 ,3 ]
机构：
[1] Stanford Univ, Sch Med, Dept Med, Div Cardiol, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
来源：
JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2010年 / 7卷
关键词：
stem cells; tumorigenicity; molecular imaging; teratoma; differentiation; regenerative medicine; IN-VIVO; TESTICULAR TERATOMAS; REPORTER GENE; PROGENITOR; EXPRESSION; APOPTOSIS; SURVIVAL; DIFFERENTIATION; DERIVATIVES; CHECKPOINT;
D O I：
10.1098/rsif.2010.0353.focus
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the ability (i) to duplicate indefinitely while maintaining pluripotency and (ii) to differentiate into cell types of all three embryonic germ layers. These two properties of ESCs and iPSCs make them potentially suitable for tissue engineering and cell replacement therapy for many different diseases, including Parkinson's disease, diabetes and heart disease. However, one critical obstacle in the clinical application of ESCs or iPSCs is the risk of teratoma formation. The emerging field of molecular imaging is allowing researchers to track transplanted ESCs or iPSCs in vivo, enabling early detection of teratomas.
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收藏
页码：S753 / S763
页数：11
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