TRANSCRANIAL SONOGRAPHY IN THE PREMOTOR DIAGNOSIS OF PARKINSON'S DISEASE

被引：13

作者：

Behnke, Stefanie ^{[1
]}

Schroeder, Ute ^{[1
]}

Berg, Daniela ^{[2
,3
]}

机构：

[1] Univ Hosp Saarland, Dept Neurol, Homburg, Germany

[2] Hertie Inst Clin Brain Res, Dept Neurodegenerat, Tubingen, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

来源：

TRANSCRANIAL SONOGRAPHY IN MOVEMENT DISORDERS | 2010年 / 90卷

关键词：

SUBSTANTIA-NIGRA HYPERECHOGENICITY; OLFACTORY DYSFUNCTION; HEALTHY CONTROLS; ECHOGENICITY; DEPRESSION; RISK; SUSCEPTIBILITY; ABNORMALITIES; ASSOCIATION; RELATIVES;

D O I：

10.1016/S0074-7742(10)90007-X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Substantia nigra hyperechogenicity (SN+) is a common finding in transcranial ultrasound studies of parkinsonian patients. However, this echofeature is also found in 10% of healthy controls and is here associated with PD risk factors such as male gender and positive family history for PD, as well as with putative premotor symptoms such as hyposmia, depression, sleep disturbances, and subtle neuropsychological and motor impairment. SN+ is hypothesized to indicate an increased risk to develop PD during lifetime. PET studies substantiate this hypothesis, given that SN+ controls showed reduced striatal [(18)Fluoro] Dopa uptake in PET studies. First results of longitudinal follow-up studies show a higher relative risk for future PD in SN+ asymptomatic individuals.

引用

页码：93 / 106

页数：14

共 47 条

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