Relevance of Subjective Cognitive Decline in Older Adults with a First-Degree Family History of Alzheimer's Disease

被引：8

作者：

Wolfsgruber, Steffen ^{[1
,2
]}

Kleineidam, Luca ^{[1
,2
]}

Weyrauch, Anne-Sophie ^{[1
,2
]}

Barkhoff, Miriam ^{[1
]}

Roeske, Sandra ^{[1
]}

Peters, Oliver ^{[3
,4
]}

Preis, Lukas ^{[4
]}

Gref, Daria ^{[4
]}

Spruth, Eike Jakob ^{[3
,5
]}

Altenstein, Slawek ^{[3
,5
]}

Priller, Josef ^{[3
,5
,6
]}

Fliessbach, Klaus ^{[1
,2
]}

Schneider, Anja ^{[1
,2
]}

Wiltfang, Jens ^{[7
,8
,9
]}

Bartels, Claudia ^{[8
]}

Jessen, Frank ^{[1
,10
,11
]}

Maier, Franziska ^{[10
]}

Duezel, Emrah ^{[12
,13
]}

Metzger, Coraline ^{[12
,13
,14
]}

Glanz, Wenzel ^{[12
]}

Buerger, Katharina ^{[15
,16
]}

Janowitz, Daniel ^{[16
]}

Perneczky, Robert ^{[15
,17
,18
,19
]}

Rauchmann, Boris-Stephan ^{[17
]}

Kilimann, Ingo ^{[20
,21
]}

Teipel, Stefan ^{[20
,21
]}

Laske, Christoph ^{[22
,23
,24
]}

Munk, Matthias H. ^{[22
,23
,24
]}

Roy, Nina ^{[1
]}

Spottke, Annika ^{[1
,25
]}

Ramirez, Alfredo ^{[1
,2
,26
]}

Heneka, Michael T. ^{[1
,2
]}

Brosseron, Frederic ^{[1
,2
]}

Wagner, Michael ^{[1
,2
]}

机构：

[1] German Ctr Neurodegenerat Dis DZNE, Venusberg Campus 1, D-53127 Bonn, Germany

[2] Univ Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat Psychi, Med Ctr, Bonn, Germany

[3] German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

[4] Charite Univ Med Berlin, Dept Psychiat, Campus Benjamin Franklin, Berlin, Germany

[5] Charite, Dept Psychiat & Psychotherapy, Berlin, Germany

[6] Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany

[7] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[8] Univ Goettingen, Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[9] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[10] Univ Cologne, Dept Psychiat, Med Fac, Cologne, Germany

[11] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

[12] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[13] Otto von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

[14] Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany

[15] German Ctr Neurodegenerat Dis DZNE Munich, Munich, Germany

[16] Ludwig Maximilians Univ Munchen, Inst Stroke & Dementia Res, Univ Hosp, Munich, Germany

[17] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Munich, Germany

[18] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[19] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit Age, London, England

[20] German Ctr Neurodegenerat Dis DZNE, Rostock, Germany

[21] Rostock Univ, Dept Psychosomat Med, Med Ctr, Rostock, Germany

[22] German Ctr Neurodegenerat Dis DZNE, Tubingen, Germany

[23] Univ Tubingen, Hertie Inst Clin Brain Res, Sect Dementia Res, Tubingen, Germany

[24] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen, Germany

[25] Univ Bonn, Dept Neurol, Med Ctr, Bonn, Germany

[26] Univ Cologne, Dept Psychiat, Div Neurogenet & Mol Psychiat, Med Fac, Cologne, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2022年 / 87卷 / 02期

关键词：

Alzheimer's disease; cerebrospinal fluid; family history; subjective cognitive decline; MEMORY COMPLAINTS; INDIVIDUALS; FRAMEWORK; RISK;

D O I：

10.3233/JAD-215416

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: It is unclear whether subjective cognitive decline (SCD) is a relevant clinical marker of incipient Alzheimer's disease (AD) and future cognitive deterioration in individuals with a family history of AD (FHAD). Objective: To investigate the association of SCD with cross-sectional cerebrospinal fluid (CSF) AD biomarker levels and cognitive decline in cognitively normal older adults with or without a first-degree FHAD. Methods: We analyzed data from cognitively normal individuals with first-degree FHAD (n = 82 "AD relatives"; mean age: 65.7 years (SD = 4.47); 59% female) and a similar group of n = 236 healthy controls without FHAD from the DELCODE study. We measured SCD with an in-depth structured interview from which we derived a SCD score, capturing features proposed to increase likelihood of underlying AD ("SCD-plus score"). We tested whether higher SCD-plus scores were associated with more pathological CSF AD biomarker levels and cognitive decline over time and whether this association varied by group. Results: AD relatives showed higher SCD-plus scores than healthy controls and more cognitive decline over time. Higher SCD-plus scores also related stronger to cognitive change and abnormal CSF AD biomarker levels in the AD relatives as compared to the healthy controls group. Conclusion: Quantification of specific SCD features can provide further information on the likelihood of early AD pathology and cognitive decline among AD relatives. FHAD and SCD appear as synergistically acting enrichment strategies in AD research, the first one as a permanent indicator of genetic risk, the latter one as a correlate of disease progression.

引用

页码：545 / 555

页数：11

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