Accounting for reciprocal host-microbiome interactions in experimental science

被引：200

作者：

Stappenbeck, Thaddeus S. ^{[1
]}

Virgin, Herbert W. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pathol & Immunol, Campus Box 8118,660 South Euclid Ave, St Louis, MO 63110 USA

来源：

NATURE | 2016年 / 534卷 / 7606期

关键词：

GUT MICROBIOTA; INTESTINAL MICROBIOTA; BACTERIAL MICROBIOME; ENTERIC VIRUS; MOUSE MODEL; DISEASE; VIROME; INFECTION; IMMUNODEFICIENCY; METABOLITES;

D O I：

10.1038/nature18285

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammals are defined by their metagenome, a combination of host and microbiome genes. This knowledge presents opportunities to further basic biology with translation to human diseases. However, the now-documented influence of the metagenome on experimental results and the reproducibility of in vivo mammalian models present new challenges. Here we provide the scientific basis for calling on all investigators, editors and funding agencies to embrace changes that will enhance reproducible and interpretable experiments by accounting for metagenomic effects. Implementation of new reporting and experimental design principles will improve experimental work, speed discovery and translation, and properly use substantial investments in biomedical research.

引用

页码：191 / 199

页数：9

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