Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

被引：1455

作者：

Tanzi, RE ^{[1
]}

Bertram, L ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med,Mass Gen Inst Neurodegenerat Dis, Dept Neurol,Genet & Aging Res Unit, Charlestown, MA 02129 USA

来源：

CELL | 2005年 / 120卷 / 04期

关键词：

D O I：

10.1016/j.cell.2005.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's biochemical dissection of beta-amyloid in 1984, the "amyloid hypothesis" of Alzheimer's disease has continued to gain support over the past two decades, particularly from genetic studies. Here we assess the amyloid hypothesis based on both known and putative Alzheimer's disease genes.

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页码：545 / 555

页数：11

相关论文

共 106 条

[1] Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease [J].

Abraham, R ;

Myers, A ;

Wavrant-DeVrieze, F ;

Hamshere, ML ;

Thomas, HV ;

Marshall, H ;

Compton, D ;

Spurlock, G ;

Turic, D ;

Hoogendoorn, B ;

Kwon, KM ;

Petersen, RC ;

Tangalos, E ;

Norton, J ;

Morris, JC ;

Bullock, R ;

Liolitsa, S ;

Lovestone, S ;

Hardy, J ;

Goate, A ;

O'Donovan, M ;

Williams, J ;

Owen, MJ ;

Jones, L .

HUMAN GENETICS, 2001, 109 (06) :646-652

[2]

Alzheimer A., 1907, ALLG Z PSYCHIAT, V64, P146, DOI DOI 10.1002/CA.980080612

[3] Polymorphisms in the promoter of the human APP gene - Functional evaluation and allele frequencies in Alzheimer disease [J].

Athan, ES ;

Lee, JH ;

Arriaga, A ;

Mayeux, RP ;

Tycko, B .

ARCHIVES OF NEUROLOGY, 2002, 59 (11) :1793-1799

[4] Microglial interaction with β-amyloid:: Implications for the pathogenesis of Alzheimer's disease [J].

Bamberger, ME ;

Landreth, GE .

MICROSCOPY RESEARCH AND TECHNIQUE, 2001, 54 (02) :59-70

[5] Alzheimer's disease: one disorder, too many genes? [J].

Bertram, L ;

Tanzi, RE .

HUMAN MOLECULAR GENETICS, 2004, 13 :R135-R141

[6] PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample [J].

Bertram, L ;

Menon, R ;

Mullin, K ;

Parkinson, M ;

Bradley, ML ;

Blacker, D ;

Tanzi, RE .

NEUROLOGY, 2004, 62 (02) :304-306

[7] Evidence for genetic linkage of Alzheimer's disease to chromosome 10q [J].

Bertram, L ;

Blacker, D ;

Mullin, K ;

Keeney, D ;

Jones, J ;

Basu, S ;

Yhu, S ;

McInnis, MG ;

Go, RCP ;

Vekrellis, K ;

Selkoe, DJ ;

Saunders, AJ ;

Tanzi, RE .

SCIENCE, 2000, 290 (5500) :2302-+

[8] Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies [J].

Bertram, L ;

Blacker, D ;

Crystal, A ;

Mullin, K ;

Keeney, D ;

Jones, J ;

Basu, S ;

Yhu, S ;

Guénette, S ;

McInnis, M ;

Go, R ;

Tanzi, R .

EXPERIMENTAL GERONTOLOGY, 2000, 35 (9-10) :1353-1361

[9] Insulin-degrading enzyme and Alzheimer disease - A genetic association study in the Han Chinese [J].

Bian, L ;

Yang, JD ;

Guo, TW ;

Sun, Y ;

Duan, SW ;

Chen, WY ;

Pan, YX ;

Feng, GY ;

He, L .

NEUROLOGY, 2004, 63 (02) :241-245

[10] ApoE-4 and age at onset of Alzheimer's disease: The NIMH genetics initiative [J].

Blacker, D ;

Haines, JL ;

Rodes, L ;

Terwedow, H ;

Go, RCP ;

Harrell, LE ;

Perry, RT ;

Bassett, SS ;

Chase, G ;

Meyers, D ;

Albert, MS ;

Tanzi, R .

NEUROLOGY, 1997, 48 (01) :139-147

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