Twenty years of the Alzheimer's disease amyloid hypothesis: A genetic perspective

被引：1435

作者：

Tanzi, RE ^{[1
]}

Bertram, L ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med,Mass Gen Inst Neurodegenerat Dis, Dept Neurol,Genet & Aging Res Unit, Charlestown, MA 02129 USA

来源：

CELL | 2005年 / 120卷 / 04期

关键词：

D O I：

10.1016/j.cell.2005.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From Alois Alzheimer's description of Auguste D.'s brain in 1907 to George Glenner's biochemical dissection of beta-amyloid in 1984, the "amyloid hypothesis" of Alzheimer's disease has continued to gain support over the past two decades, particularly from genetic studies. Here we assess the amyloid hypothesis based on both known and putative Alzheimer's disease genes.

引用

页码：545 / 555

页数：11

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