Three new compounds from the roots of Juglans mandshurica Maxim

被引：12

作者：

Li, Jing ^{[1
]}

Xu, Ping-Sheng ^{[2
]}

Zou, Zhen-Xing ^{[1
,2
]}

Zou, Hui ^{[1
]}

Long, Hong-Ping ^{[3
]}

Tan, Lei-Hong ^{[1
]}

Liu, Rui-Huan ^{[1
]}

Wang, Yi-Kun ^{[1
]}

Xu, Kang-Ping ^{[1
]}

Tan, Gui-Shan ^{[1
,2
]}

机构：

[1] Cent S Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China

[3] Hunan Univ Chinese Med, Hosp 1, Changsha 410007, Hunan, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2017年 / 20卷

关键词：

Juglans mandshurica Maxim; Biflavone glycoside; Juglbiflavone a; Triterpenoid; Cytotoxicity; STEM-BARK; DIARYLHEPTANOIDS; CONSTITUENTS; NAPHTHOQUINONES; LEAVES;

D O I：

10.1016/j.phytol.2017.03.014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new biflavone glycoside juglbiflavone A (1) along with two new lupane-type triterpenes (2-3) were identified from the roots of Juglans mandshurica Maxim. Their structures and absolute configurations were elucidated by extensive spectroscopic methods including 1D/2D NMR, HRESIMS and CD. Compound 1 is the first example of biflavone glycoside consisted of a flavanol unit and a flavone unit from this genus, which also exhibited moderate cytotoxic activity against SGC-7901 and A549 cell lines in vitro with IC50 values of 10.08 +/- 0.52 mu M and 12.44 +/- 1.21 mu M, respectively.

引用

页码：40 / 44

页数：5

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