Combined semantic dementia and apraxia in a patient with frontotemporal lobar degeneration

被引：9

作者：

Schumann, G

Halsband, U

Kassubek, J

Gustin, S

Heinks, T

Juengling, FD

Hüll, M

机构：

[1] Univ Freiburg, Dept Psychiat, Freiburg, Germany

[2] Univ Freiburg, Dept Psychol, Freiburg, Germany

[3] Univ Freiburg, Dept Neurol, Freiburg, Germany

[4] Univ Freiburg, Dept Nucl Med, Freiburg, Germany

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2000年 / 100卷 / 01期

关键词：

frontotemporal lobar degeneration; semantic dementia; apraxia; 3-D MRI; FDG-PET;

D O I：

10.1016/S0925-4927(00)00065-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this study we report neuropsychological and brain-imaging findings in a patient with frontotemporal lobar degeneration. Brain imaging using registration of (18)fluorodeoxyglucose (FDG)-PET data to three-dimensional (3-D) magnetic resonance imaging showed atrophy and highly significant hypometabolism of the left temporal lobe and both frontal lobes. Volumetric measurements of the hippocampi/amygdala showed a reduction in volume of 25% on the left compared to right within cortical areas. Neuropsychological testing revealed semantic dementia with severe anemia as well as apraxia with impairment of both recognition and production of motor acts. The implications of this case of early manifestation of frontotemporal lobar degeneration for our knowledge of dementia are discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：21 / 29

页数：9

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