Electrochemical Quantitative Detection of Glial Fibrillary Acidic Protein Based on Molecularly Imprinted Polymer Sensor

被引：20

作者：

Wang, Tao ^{[1
]}

Fang, Yuan ^{[2
]}

He, Zhongzheng

机构：

[1] Cent Hosp Xian, Dept Neurosurg, Xian 710004, Shaanxi, Peoples R China

[2] Third Hosp Xian, Dept Neurosurg, Xian 710018, Shaanxi, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE | 2017年 / 12卷 / 08期

关键词：

Glial fibrillary acidic protein; Molecularly imprinted polymer; Nervous system; Electrochemical determination; Human blood serum; CARBON NANOTUBE; INJURY; BLOOD; CELLS; GENE; GFAP;

D O I：

10.20964/2017.08.69

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

This study synthesized a new glial fibrillary acidic protein (GFAP)-imprinted polymer based on the principle of biomimiking. A carbon electrode printed using an imprinted polymer-modified screen was constructed under, 'grafting-to'. modification for the detection of the GFAP. Then the atomic force microscopy and scanning electron microscopy assays were employed for the characterization of the decorated surface, with the limit of detection (LOD) of 0.04 mu g/mL obtained under aqueous circumstance. The GFAP determination was further investigated in human blood serum to confirm the methodology and effect of the developed sensor.

引用

页码：7341 / 7350

页数：10

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