Pulmonary metastasis from giant cell tumor of bone: clinical outcome prior to the introduction of molecular target therapy

被引:19
作者
Kito, Munehisa [1 ]
Matusmoto, Seiichi [1 ]
Ae, Keisuke [1 ]
Tanizawa, Taisuke [1 ]
Gokita, Tabu [1 ]
Kobayashi, Hiroshi [1 ]
Hayakawa, Keiko [1 ]
Funauchi, Yuki [1 ]
机构
[1] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Orthopaed Surg, Tokyo, Japan
关键词
giant cell tumor of bone; pulmonary metastasis; local recurrence; metastasectomy; follow-up period; LUNG METASTASES;
D O I
10.1093/jjco/hyx033
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: We analyzed the risk factors for pulmonary metastasis from giant cell tumor of bone and aimed to discuss their therapeutic strategy and appropriate follow-up period. Methods: We analyzed 141 patients of giant cell tumor of bone. The variables analyzed included age, gender, primary site, Campanacci grading, surgical treatment on the primary lesion, radiotherapy and local recurrence. Results: Pulmonary metastasis occurred in 12 patients. The risk factors were young age, Campanacci Grade Ill and local recurrence. Median time from initial surgery to metastasis was 1.3 years (0-3.1 years). Among them, eight patients experienced local recurrence of the primary tumor, and the median time from initial surgery to local recurrence was 0.8 years (0.3-2.9 years). Among seven patients who underwent wide resection, three patients showed local recurrence of the soft tissue. Nine patients underwent metastasectomy for pulmonary metastases. Of three patients who did not undergo metastasectomy, one patient died of uncontrollable metastases, and two patients showed no changes in their metastatic lesions. Conclusions: Although we found a correlation between local recurrence and pulmonary metastasis, we were still unable to prevent local or metastatic recurrence by wide resection. Local recurrence and metastasis have been found within 3 years after initial surgery, and routine image examinations of the primary site and chest after initial surgical treatment should be considered for at least 3 years postoperatively.
引用
收藏
页码:529 / 534
页数:6
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