Organosilane self-assembled monolayer-modified field effect transistors for on-chip ion and biomolecule sensing

被引：36
作者：
Niwa, D
Omichi, K
Motohashi, N
Homma, T
Osaka, T [1 ]
机构：
[1] Waseda Univ, Inst Biomed Engn, Shinjuku Ku, Tokyo 1698555, Japan
[2] Waseda Univ, Dept Appl Chem, Shinjuku Ku, Tokyo 1698555, Japan
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2005年 / 108卷 / 1-2期
关键词：
on-chip biosensing device; ion and biomolecule detection; reference device; self-assembled monolayer; field effect transistor;
D O I：
10.1016/j.snb.2004.11.055
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Field effect transistors (FETs) modified with various functional monolayers, such as organosilane monolayer, were formed on the identical substrate by precise control of the fabrication processes. The devices showed a typical transistor property with a good stability in aqueous solutions. The amino monolayer-modified FET acted as an ion sensitive FET with a good pH sensitivity of 58 mV/pH, and the perfluoro-alkyl monolayer-modified FET worked as a reference device. Moreover, the device with enzyme immobilized onto amino modified gate electrode enabled to detect trace concentration (10(-9) to 10(-6) M) of urea with a high sensitivity of 64 mV/decade. These monolayer-modified devices were expected to be applied as working and reference electrodes for on-chip ion and biosensing. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：721 / 726
页数：6
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