Myelodysplastic Syndrome with Ph Negative Monosomy 7 Chromosome following Transient Bone Marrow Dysplasia during Imatinib Treatment for Chronic Myeloid Leukemia

被引：15

作者：

Karimata, Kaori ^{[2
]}

Masuko, Masayoshi ^{[1
]}

Ushiki, Takashi ^{[2
]}

Kozakai, Takashi ^{[2
]}

Shibasaki, Yasuhiko ^{[2
]}

Yano, Toshio ^{[2
]}

Abe, Takashi ^{[2
]}

Moriyama, Masato ^{[2
]}

Toba, Ken ^{[2
]}

Furukawa, Tatsuo ^{[1
]}

Aizawa, Yoshifusa ^{[2
]}

机构：

[1] Niigata Univ, Med & Dent Hosp, Div Stem Cell Transplantat, Niigata 95021, Japan

[2] Niigata Univ, Med & Dent Hosp, Div Hematol, Niigata 95021, Japan

来源：

INTERNAL MEDICINE | 2011年 / 50卷 / 05期

关键词：

CML; MDS; monosomy; 7; Ph negative cells; CLONAL CYTOGENETIC ABNORMALITIES; CHRONIC MYELOGENOUS LEUKEMIA; MESYLATE THERAPY; TYROSINE KINASE; CHRONIC-PHASE; CML PATIENTS; CELLS; HEMATOPOIESIS; DASATINIB; EMERGENCE;

D O I：

10.2169/internalmedicine.50.4481

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe a 60-year-old Japanese patient with chronic myeloid leukemia (CML) who developed myelodysplastic syndrome (MDS) with Ph negative monosomy 7 chromosome following transient bone marrow dysplasia during imatinib treatment. Most cases that developed chromosomal abnormality in Ph negative cells during imatinib therapy were reported to have less clinical implications, while rare cases developed MDS/AML. The present case suggested that metaphase karyotype analysis and bone marrow examination should be performed for the long term follow-up under imatinib treatment in cases showing cytopenia. The results also suggested that monosomy 7 in Ph negative cells may be an indicator of a poor prognosis.

引用

页码：481 / 485

页数：5

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