Intracellular processing of aggregated tan differs between corticobasal degeneration and progressive supranuclear palsy

被引：31
作者：
Arai, T
Ikeda, K
Akiyama, H
Tsuchiya, K
Yagishita, S
Takamatsu, J
机构：
[1] Tokyo Inst Psychiat, Dept Neuropathol, Setagaya Ku, Tokyo 1568585, Japan
[2] Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan
[3] Kanagawa Rehabil Ctr, Div Pathol, Atsugi, Kanagawa 24301, Japan
[4] Kikuchi Natl Hosp, Div Clin Res, Kumamoto 86111, Japan
来源：
NEUROREPORT | 2001年 / 12卷 / 05期
关键词：
immunoblot; proteolysis; aggregate; fragment; isoform;
D O I：
10.1097/00001756-200104170-00014
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) are sporadic neurodegenerative diseases with intracytoplasmic aggregates of the microtubule-associated protein, tau, in neurons and glial cells. Immunoblot analysis of detergent-insoluble brain extracts of patients with CBD and PSP shows distinctive patterns of tau fragments. These results suggest differing intracellular processing of aggregated tau in these two diseases despite an identical composition of tau isoforms. Such biochemical differences may be related to the neuropathological features of these diseases. NeuroReport 12:935-938 (C) 2001 Lippincott Williams & Wilkins.
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收藏
页码：935 / 938
页数：4
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