CDK5 in oncology: recent advances and future prospects

被引：33

作者：

Lenjisa, Jimma Likisa ^{[1
]}

Tadesse, Solomon ^{[1
]}

Khair, Nishat Zareen ^{[1
]}

Kumarasiri, Malika ^{[1
]}

Yu, Mingfeng ^{[1
]}

Albrecht, Hugo ^{[1
]}

Milne, Robert ^{[1
]}

Wang, Shudong ^{[1
]}

机构：

[1] Univ South Australia, Ctr Drug Discovery & Dev, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia

来源：

FUTURE MEDICINAL CHEMISTRY | 2017年 / 9卷 / 16期

关键词：

cancer; cancer hallmarks; CDK; CDK5; inhibitors; p25; p35; targeted cancer therapy; CYCLIN-DEPENDENT KINASE-5; LUNG-CANCER CELLS; DNA-DAMAGE; HEPATOCELLULAR-CARCINOMA; BIOLOGICAL EVALUATION; INHIBITOR DINACICLIB; POTENTIAL TREATMENT; REGULATORY PROTEIN; TUMOR ANGIOGENESIS; ANDROGEN RECEPTOR;

D O I：

10.4155/fmc-2017-0097

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Selective abrogation of cyclin-dependent kinases (CDK) activity is a highly promising strategy in cancer treatment. The atypical CDK, CDK5 has long been known for its role in neurodegenerative diseases, and is becoming an attractive drug target for cancer therapy. Myriads of recent studies have uncovered that aberrant expression of CDK5 contributes to the oncogenic initiation and progression of multiple solid and hematological malignancies. CDK5 is also implicated in the regulation of cancer stem cell biology. In this review, we present the current state of knowledge of CDK5 as a druggable target for cancer treatment. We also provide a detailed outlook of designing selective and potent inhibitors of this enzyme.

引用

页码：1939 / 1962

页数：24

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