Unlocking the Role of Exercise on CD4+T Cell Plasticity

被引：2

作者：

Goldsmith, Chloe D. ^{[1
]}

Donovan, Thomasina ^{[1
,2
,3
]}

Vlahovich, Nicole ^{[4
]}

Pyne, David B. ^{[1
,5
]}

机构：

[1] Univ Canberra, Res Inst Sport & Exercise, Canberra, ACT, Australia

[2] Queensland Univ Technol, Fac Hlth, Australian Ctr Hlth Serv Innovat, Brisbane, Qld, Australia

[3] Queensland Univ Technol, Fac Hlth, Ctr Healthcare Transformat, Sch Publ Hlth & Social Work, Brisbane, Qld, Australia

[4] Univ Canberra, Fac Hlth, Canberra, ACT, Australia

[5] Canterbury Christ Church Univ, Fac Sci Engn & Social Sci, Sch Psychol & Life Sci, Canterbury, Kent, England

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

immune; epigenetics; metabolism; DNA methylation; chromatin remodeling; histone modification; mitochondria; DIFFERENTIATION; HOMOCYSTEINE; MECHANISMS; EXPRESSION; GLUT1; VIEW; TH17;

D O I：

10.3389/fimmu.2021.729366

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A hallmark of T cell ageing is a loss of effector plasticity. Exercise delays T cell ageing, yet the mechanisms driving the effects of exercise on T cell biology are not well elucidated. T cell plasticity is closely linked with metabolism, and consequently sensitive to metabolic changes induced by exercise. Mitochondrial function is essential for providing the intermediate metabolites necessary to generate and modify epigenetic marks in the nucleus, thus metabolic activity and epigenetic mechanisms are intertwined. In this perspective we propose a role for exercise in CD4+ T cell plasticity, exploring links between exercise, metabolism and epigenetic reprogramming.

引用

页数：8

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