Unlocking the Role of Exercise on CD4+T Cell Plasticity

被引:2
作者
Goldsmith, Chloe D. [1 ]
Donovan, Thomasina [1 ,2 ,3 ]
Vlahovich, Nicole [4 ]
Pyne, David B. [1 ,5 ]
机构
[1] Univ Canberra, Res Inst Sport & Exercise, Canberra, ACT, Australia
[2] Queensland Univ Technol, Fac Hlth, Australian Ctr Hlth Serv Innovat, Brisbane, Qld, Australia
[3] Queensland Univ Technol, Fac Hlth, Ctr Healthcare Transformat, Sch Publ Hlth & Social Work, Brisbane, Qld, Australia
[4] Univ Canberra, Fac Hlth, Canberra, ACT, Australia
[5] Canterbury Christ Church Univ, Fac Sci Engn & Social Sci, Sch Psychol & Life Sci, Canterbury, Kent, England
来源
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词
immune; epigenetics; metabolism; DNA methylation; chromatin remodeling; histone modification; mitochondria; DIFFERENTIATION; HOMOCYSTEINE; MECHANISMS; EXPRESSION; GLUT1; VIEW; TH17;
D O I
10.3389/fimmu.2021.729366
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A hallmark of T cell ageing is a loss of effector plasticity. Exercise delays T cell ageing, yet the mechanisms driving the effects of exercise on T cell biology are not well elucidated. T cell plasticity is closely linked with metabolism, and consequently sensitive to metabolic changes induced by exercise. Mitochondrial function is essential for providing the intermediate metabolites necessary to generate and modify epigenetic marks in the nucleus, thus metabolic activity and epigenetic mechanisms are intertwined. In this perspective we propose a role for exercise in CD4+ T cell plasticity, exploring links between exercise, metabolism and epigenetic reprogramming.
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页数:8
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共 49 条
  • [1] An epigenetic view of helper T cell differentiation
    Ansel, KM
    Lee, DU
    Rao, A
    [J]. NATURE IMMUNOLOGY, 2003, 4 (07) : 616 - 623
  • [2] Exercise as a therapeutic option for acute kidney injury: mechanisms and considerations for the design of future clinical studies
    Asad, Anam
    Burton, James O.
    March, Daniel S.
    [J]. BMC NEPHROLOGY, 2020, 21 (01)
  • [3] An immunoregulatory and tissue-residency program modulated by c-MAF in human TH17 cells
    Aschenbrenner, Dominik
    Foglierini, Mathilde
    Jarrossay, David
    Hu, Dan
    Weiner, Howard L.
    Kuchroo, Vijay K.
    Lanzavecchia, Antonio
    Notarbartolo, Samuele
    Sallusto, Federica
    [J]. NATURE IMMUNOLOGY, 2018, 19 (10) : 1126 - +
  • [4] A metabolic view on menopause and ageing
    Auro, Kirsi
    Joensuu, Anni
    Fischer, Krista
    Kettunen, Johannes
    Salo, Perttu
    Mattsson, Hannele
    Niironen, Marjo
    Kaprio, Jaakko
    Eriksson, Johan G.
    Lehtimaki, Terho
    Raitakari, Olli
    Jula, Antti
    Tiitinen, Aila
    Jauhiainen, Matti
    Soininen, Pasi
    Kangas, Antti J.
    Kahonen, Mika
    Havulinna, Aki S.
    Ala-Korpela, Mika
    Salomaa, Veikko
    Metspalu, Andres
    Perola, Markus
    [J]. NATURE COMMUNICATIONS, 2014, 5
  • [5] Foxp3-mediated inhibition of Akt inhibits Glut1 (glucose transporter 1) expression in human T regulatory cells
    Basu, Samik
    Hubbard, Britany
    Shevach, Ethan M.
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2015, 97 (02) : 279 - 283
  • [6] Functional and Phenotypic Plasticity of CD4+ T Cell Subsets
    Caza, Tiffany
    Landas, Steve
    [J]. BIOMED RESEARCH INTERNATIONAL, 2015, 2015
  • [7] Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy
    Chen, Zhisong
    Yan, Wenwen
    Mao, Yu
    Ni, Yi
    Zhou, Lin
    Song, Haoming
    Xu, Wenjun
    Wang, Leming
    Shen, Yuqin
    [J]. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2018, 11 (03) : 230 - 235
  • [8] Physical Training Is a Potential Modifier of Risk for Contrast-Induced Acute Kidney Injury in Diabetes Mellitus
    Couto, Sheila M. F.
    Machado, Douglas, I
    Conde, Carolina
    Silva, Vinicius C.
    Souza, Adriana A.
    Peres, Karina B.
    Brandi, Beatriz A.
    Vattimo, Maria De Fatima F.
    [J]. BIOMED RESEARCH INTERNATIONAL, 2020, 2020
  • [9] SUBSTRATE UTILIZATION DURING EXERCISE IN ACTIVE PEOPLE
    COYLE, EF
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1995, 61 (04) : 968S - 979S
  • [10] The immunoregulatory effects of homocysteine and its intermediates on T-lymphocyte function
    Dawson, H
    Collins, G
    Pyle, R
    Deep-Dixit, V
    Taub, DD
    [J]. MECHANISMS OF AGEING AND DEVELOPMENT, 2004, 125 (02) : 107 - 110