Study of the Biological Activity of Alkyl Derivatives of Tetrahydroisoquinolines

被引：0

作者：

Khamidova, Umida ^{[1
]}

Terenteva, Ekaterina ^{[1
]}

Umarova, Mukaddas ^{[1
]}

Abdurakhmanov, Jaloliddin ^{[1
]}

Sasmakov, Sabirdjan ^{[1
]}

Makhnyov, Artyom ^{[1
]}

Vinogradova, Valentina ^{[1
]}

Saidov, Abdusalom ^{[2
]}

Khashimova, Zaynat ^{[3
]}

Azimova, Shakhnoz ^{[1
]}

机构：

[1] Acad Sci Uzbek, Inst Chem Plant Subst, Tashkent, Uzbekistan

[2] Samarkand State Univ, Samarkand, Uzbekistan

[3] Acad Sci Uzbek, Inst Bioorgan Chem, Tashkent, Uzbekistan

来源：

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL | 2021年 / 33卷 / 46B期

关键词：

Tetrahydroisoquinoline derivatives; cytotoxicity; cancer and normal cell lines; antibacterial and antifungal activity; MEDIATED MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; IN-VITRO; ANTIBACTERIAL; REVERSAL;

D O I：

10.9734/JPRI/2021/v33i46B32938

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A row of 1-alkyne (C6-C17) derivatives against tetrahydroisoquinoline have been synthesized. 1-alkyne (C6-C17) derivatives cytotoxicity against three lines of cancer cells and two lines of normal cells was studied. It was found that 1-tridecyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline exhibits a high cytotoxic effect with low toxicity to healthy cells. Antimicrobial activity of 1-alkyne (C6-C17) derivatives against 5 strains of bacteria and fungus was studied. It has been found that 1-nonyl-6,7-dimethoxy-1,3,4-tetrahydroisoquinoline exhibits strong antibacterial and antifungal effects.

引用

页码：238 / 246

页数：9

共 22 条

[11] Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase
Guzman, Juan D.
Pesnot, Thomas
Barrera, Diana A.
Davies, Heledd M.
McMahon, Eleanor
Evangelopoulos, Dimitrios
Mortazavi, Parisa N.
Munshi, Tulika
Maitra, Arundhati
Lamming, Eleanor D.
Angell, Richard
Gershater, Markus C.
Redmond, Joanna M.
Needham, Deborah
Ward, John M.
Cuca, Luis E.
Hailes, Helen C.
Bhakta, Sanjib
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2015, 70 (06) : 1691 - 1703
[12] Isolation of primary rat liver fibroblasts
Kruglov, EA
Jain, D
Dranoff, JA
[J]. JOURNAL OF INVESTIGATIVE MEDICINE, 2002, 50 (03) : 179 - 184
[13] Synthesis and pharmacological evaluation of piperidinoalkanoyl-1,2,3,4-tetrahydroisoquinoline derivatives as novel specific bradycardic agents
Kubota, H
Watanabe, T
Kakefuda, A
Masuda, N
Wada, K
Ishii, N
Sakamoto, S
Tsukamoto, S
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (12) : 3049 - 3052
[14] Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer
Li, Yu
Zhang, Hui-bin
Huang, Wen-long
Li, Yun-man
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (12) : 3652 - 3655
[15] Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy
Lin, Yong
Shi, Ranxin
Wang, Xia
Shen, Han-Ming
[J]. CURRENT CANCER DRUG TARGETS, 2008, 8 (07) : 634 - 646
[16] Manikandan A., 2016, J Pharm Sci, V8, P339
[17] TOWARDS AN OPTIMIZED MTT ASSAY
NIKS, M
OTTO, M
[J]. JOURNAL OF IMMUNOLOGICAL METHODS, 1990, 130 (01) : 149 - 151
[18] Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents
Panchaud, Philippe
Bruyere, Thierry
Blumstein, Anne-Catherine
Bur, Daniel
Chambovey, Alain
Ertel, Eric A.
Gude, Markus
Hubschwerlen, Christian
Jacob, Loic
Kimmerlin, Thierry
Pfeifer, Thomas
Prade, Lars
Seiler, Peter
Ritz, Daniel
Rueedi, Georg
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2017, 60 (09) : 3755 - 3775
[19] Synthesis and In Vitro Evaluation of Novel 1,2,3,4-Tetrahydroisoquinoline Derivatives as Potent Antiglioma Agents
Patil, Renukadevi
Hosni-Ahmed, Amira
Jones, Terreia S.
Patil, Shivaputra A.
Asres, Likeselam B.
Wang, Xiangdi
Yates, Ryan C.
Geisert, Eldon E.
Miller, Duane D.
[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2014, 14 (03) : 473 - 482
[20] Synthesis of 1-Alkyltetrahydroisoquinolines
Saidov, A. Sh
Levkovich, M. G.
Vinogradova, V. I.
[J]. CHEMISTRY OF NATURAL COMPOUNDS, 2013, 49 (05) : 897 - 901

← 1 2 3 →