Study of the Biological Activity of Alkyl Derivatives of Tetrahydroisoquinolines

被引：0

作者：

Khamidova, Umida ^{[1
]}

Terenteva, Ekaterina ^{[1
]}

Umarova, Mukaddas ^{[1
]}

Abdurakhmanov, Jaloliddin ^{[1
]}

Sasmakov, Sabirdjan ^{[1
]}

Makhnyov, Artyom ^{[1
]}

Vinogradova, Valentina ^{[1
]}

Saidov, Abdusalom ^{[2
]}

Khashimova, Zaynat ^{[3
]}

Azimova, Shakhnoz ^{[1
]}

机构：

[1] Acad Sci Uzbek, Inst Chem Plant Subst, Tashkent, Uzbekistan

[2] Samarkand State Univ, Samarkand, Uzbekistan

[3] Acad Sci Uzbek, Inst Bioorgan Chem, Tashkent, Uzbekistan

来源：

JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL | 2021年 / 33卷 / 46B期

关键词：

Tetrahydroisoquinoline derivatives; cytotoxicity; cancer and normal cell lines; antibacterial and antifungal activity; MEDIATED MULTIDRUG-RESISTANCE; P-GLYCOPROTEIN; IN-VITRO; ANTIBACTERIAL; REVERSAL;

D O I：

10.9734/JPRI/2021/v33i46B32938

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A row of 1-alkyne (C6-C17) derivatives against tetrahydroisoquinoline have been synthesized. 1-alkyne (C6-C17) derivatives cytotoxicity against three lines of cancer cells and two lines of normal cells was studied. It was found that 1-tridecyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline exhibits a high cytotoxic effect with low toxicity to healthy cells. Antimicrobial activity of 1-alkyne (C6-C17) derivatives against 5 strains of bacteria and fungus was studied. It has been found that 1-nonyl-6,7-dimethoxy-1,3,4-tetrahydroisoquinoline exhibits strong antibacterial and antifungal effects.

引用

页码：238 / 246

页数：9

共 22 条

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