Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss

被引：25

作者：

Ikeuchi, Tomoko ^{[1
]}

Moutsopoulos, Niki M. ^{[1
]}

机构：

[1] Natl Inst Dent & Craniofacial Res, Oral Immun & Infect Sect, NIH, 9000 Rockville Pike,30 Convent Dr,Bldg30,Room 327, Bethesda, MD 20892 USA

来源：

BONE | 2022年 / 163卷

关键词：

Osteoimmunology; Periodontitis; Th17; cells; Oral microbiome; Bone loss; COLLAGEN-INDUCED ARTHRITIS; TNF-ALPHA THERAPY; RHEUMATOID-ARTHRITIS; ALVEOLAR BONE; TH17; CELLS; JOINT INFLAMMATION; ORAL MICROBIOME; RECEPTOR; RANKL; HEALTH;

D O I：

10.1016/j.bone.2022.116500

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Periodontitis is a prevalent human disease of inflammation-induced bone destruction. Through studies in patient lesions of rare and common forms of periodontitis and animal model experimentation, Th17/IL-17 related im-mune pathways have emerged as mediators of disease pathology. In this focused review, we examine mecha-nisms of induction, amplification and pathogenicity of Th17 cells in periodontitis.

引用

页数：9

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