Nonhuman primate models of measles

被引：0

作者：

Kobune, F

Takahashi, H

Terao, K

Ohkawa, T

Ami, Y

Suzaki, Y

Nagata, N

Sakata, H

Yamanouchi, K

Kai, C

机构：

[1] NATL INST HLTH, DEPT SAFETY RES BIOLOG, TOKYO 208, JAPAN

[2] NATL INST HLTH, DIV EXPT ANIM RES, TOKYO 208, JAPAN

[3] NATL INST HLTH, TSUKUBA PRIMATE CTR MED SCI, TSUKUBA, IBARAKI 305, JAPAN

[4] NIPPON INST BIOL SCI, TOKYO 198, JAPAN

[5] UNIV TOKYO, FAC AGR, DEPT VET MICROBIOL, BUNKYO KU, TOKYO 113, JAPAN

来源：

LABORATORY ANIMAL SCIENCE | 1996年 / 46卷 / 03期

关键词：

D O I：

暂无

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Wild measles virus isolated in a marmoset lymphoblastoid B95a cell line induced rashes and Koplik's spots when inoculated parenterally in cynomolgus and squirrel monkeys. Marked leukopenia associated with transient decrease in the CD4(+)-to-CD8(+) T-cell ratio also was induced, Virus growth, as well as histologic lesions of necrosis and giant cell formation, was observed in the lymphoid tissues. Thus clinical signs of acute measles were successfully induced in monkeys by inoculation with cell-culture grown measles virus, These nonhuman primate models of measles will be useful for study of the pathogenesis of acute measles virus infection in terms of generalized clinical signs of disease, leukopenia, and changes in the lymphocyte subsets.

引用

页码：315 / 320

页数：6

共 18 条

[1] FATAL MEASLES INFECTION IN MARMOSETS PATHOGENESIS AND PROPHYLAXIS [J].