A practical Cu(I)-catalyzed domino approach to 1,2-disubstituted indoles and its application for the assembly of indolophenanthridines

被引：8

作者：

Gao, Jilong ^{[1
]}

Xu, Bingqing ^{[1
]}

Zhu, Jiaqi ^{[1
]}

Shao, Yingying ^{[1
]}

Chen, Lubin ^{[1
]}

Zhu, Jiaoyan ^{[1
]}

Wang, Xiaxia ^{[1
]}

Lv, Xin ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Coll Chem & Life Sci, Dept Chem, Jinhua 321004, Peoples R China

来源：

ARKIVOC | 2016年

基金：

中国国家自然科学基金;

关键词：

Copper; cross-coupling; domino reactions; indoles; fused phenanthridines; ONE-POT SYNTHESIS; C-N; SUBSTITUTED INDOLES; EFFICIENT SYNTHESIS; MODULAR SYNTHESIS; ROOM-TEMPERATURE; ARYL HALIDES; H ARYLATION; COPPER; PALLADIUM;

D O I：

10.3998/ark.5550190.p009.387

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient approach to 1,2-disubstituted indoles has been developed using a novel Cu(I)-catalyzed cascade coupling/cyclization reaction of 2-alkynylanilines with aryl iodides. Facilitated by CuI/t-BuOK without any ligand or CuI/Cs2CO3/1,10-phenanthroline, a variety of 1,2-disubstituted indoles were conveniently generated in one pot with good to excellent yields. Furthermore, a series of indolo[1,2-f] phenanthridines were successfully assembled from the tandem reactions of 2-alkynylanilines with o-dihaloarenes through copper-catalyzed coupling / cyclization followed by palladium-catalyzed intramolecular direct C(sp(2))-H arylation.

引用

页码：1 / 14

页数：14

共 11 条

[1] One-Pot Approach to 1,2-Disubstituted Indoles via Cu(II)-Catalyzed Coupling/Cyclization under Aerobic Conditions and Its Application for the Synthesis of Polycyclic Indoles
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