The emerging roles of forkhead box (Fox) proteins in cancer

被引：952
作者：
Myatt, Stephen S. [1 ]
Lam, Eric W. -F. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Dept Oncol, Canc Res UK Lab, London W12 0NN, England
来源：
NATURE REVIEWS CANCER | 2007年 / 7卷 / 11期
基金：
英国生物技术与生命科学研究理事会;
关键词：
D O I：
10.1038/nrc2223
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional regulators, which control a wide spectrum of biological processes. As a consequence, a loss or gain of Fox function can alter cell fate and promote tumorigenesis as well as cancer progression. Here we discuss the evidence that the deregulation of Fox family transcription factors has a crucial role in the development and progression of cancer, and evaluate the emerging role of Fox proteins as direct and indirect targets for therapeutic intervention, as well as biomarkers for predicting and monitoring treatment responses.
引用
收藏
页码：847 / 859
页数：13
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