Copper catalysed alkynylation of tertiary amines with CaC2 via sp3 C-H activation

被引：66

作者：

Teong, Siew Ping ^{[1
]}

Yu, Dingyi ^{[1
]}

Sum, Yin Ngai ^{[1
]}

Zhang, Yugen ^{[1
]}

机构：

[1] The Nanos, Inst Bioengn & Nanotechnol, 31 Biopolis Way, Singapore 138669, Singapore

来源：

GREEN CHEMISTRY | 2016年 / 18卷 / 12期

关键词：

ONE-POT SYNTHESIS; CALCIUM CARBIDE; TERMINAL ALKYNES; PROPARGYLIC AMINES; DIRECT-ADDITION; BONDS ADJACENT; DERIVATIVES; ALDEHYDES; CRYSTAL;

D O I：

10.1039/c6gc00872k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A mild and easy-to-handle protocol to produce propargylamines with a terminal alkyne through catalytic cross-coupling of tertiary amines and calcium carbide has been developed. The reaction proceeds via sp(3) C-H bond activation and C-C coupling. Good to excellent yields were obtained for the corresponding propargylamines with both alkyl and aryl substitutions. The development of these functionalized propargylamines with a terminal alkyne group will offer a wider application for the synthesis of natural or pharmaceutical products due to their unique sp C-H reactivity.

引用

页码：3499 / 3502

页数：4

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